{"title":"黑草油和α硫辛酸对阿米卡星致家兔肝肾毒性的作用","authors":"A. Zohree, A. M. Abdelmoteleb, O. Hamed","doi":"10.21608/ejah.2022.276336","DOIUrl":null,"url":null,"abstract":"A mikacin (AK) has long been used as an effective antibiotic to prevent Gram-negative infections. Despite its numerous benefits, Amikacin has considerable hepato-renal toxic adverse effects. The potential preventive benefits of NSO, “Nigella sativa oil” and/or ALA, “Alpha lipoic acid” were investigated in rabbits with Amikacin-induced acute hepa-to- renal injury. Rabbits were treated with AK (100mg/kg BW/day I/M in-jection) alone or with NSO (2ml/kg BW orally) and /or ALA (50 mg/kg BW/day) daily for seven days. Serum biochemical parameters well as tissue oxidative stress indicators were measured to evaluatehepato-renal damage. Rabbits administered AK showed substantial changes in serum biochemical hepato-renal damage indicators with reduction in tissue antioxidant bi-omarkers and rise in hepato-renal oxidant. NSO plus ALA treatment potentially alleviated the AK induced changes in blood and tissue biochemistry. The current study","PeriodicalId":11415,"journal":{"name":"Egyptian Journal of Animal Health","volume":"22 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Role of Nigella sativa oil and Alpha lipoic acid on Amikacin induced hepatorenal toxicity in rabbits\",\"authors\":\"A. Zohree, A. M. Abdelmoteleb, O. Hamed\",\"doi\":\"10.21608/ejah.2022.276336\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"A mikacin (AK) has long been used as an effective antibiotic to prevent Gram-negative infections. Despite its numerous benefits, Amikacin has considerable hepato-renal toxic adverse effects. The potential preventive benefits of NSO, “Nigella sativa oil” and/or ALA, “Alpha lipoic acid” were investigated in rabbits with Amikacin-induced acute hepa-to- renal injury. Rabbits were treated with AK (100mg/kg BW/day I/M in-jection) alone or with NSO (2ml/kg BW orally) and /or ALA (50 mg/kg BW/day) daily for seven days. Serum biochemical parameters well as tissue oxidative stress indicators were measured to evaluatehepato-renal damage. Rabbits administered AK showed substantial changes in serum biochemical hepato-renal damage indicators with reduction in tissue antioxidant bi-omarkers and rise in hepato-renal oxidant. NSO plus ALA treatment potentially alleviated the AK induced changes in blood and tissue biochemistry. The current study\",\"PeriodicalId\":11415,\"journal\":{\"name\":\"Egyptian Journal of Animal Health\",\"volume\":\"22 1\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2022-10-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Egyptian Journal of Animal Health\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.21608/ejah.2022.276336\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Egyptian Journal of Animal Health","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.21608/ejah.2022.276336","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Role of Nigella sativa oil and Alpha lipoic acid on Amikacin induced hepatorenal toxicity in rabbits
A mikacin (AK) has long been used as an effective antibiotic to prevent Gram-negative infections. Despite its numerous benefits, Amikacin has considerable hepato-renal toxic adverse effects. The potential preventive benefits of NSO, “Nigella sativa oil” and/or ALA, “Alpha lipoic acid” were investigated in rabbits with Amikacin-induced acute hepa-to- renal injury. Rabbits were treated with AK (100mg/kg BW/day I/M in-jection) alone or with NSO (2ml/kg BW orally) and /or ALA (50 mg/kg BW/day) daily for seven days. Serum biochemical parameters well as tissue oxidative stress indicators were measured to evaluatehepato-renal damage. Rabbits administered AK showed substantial changes in serum biochemical hepato-renal damage indicators with reduction in tissue antioxidant bi-omarkers and rise in hepato-renal oxidant. NSO plus ALA treatment potentially alleviated the AK induced changes in blood and tissue biochemistry. The current study
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