DISSEMINATED KAPOSI'S SARCOMA IN PATIENT WITH HUMAN IMMUNODEFICIENCY VIRUS INFECTION

Kaposi's carcoma is the most common AIDS-defining malignancy.With the introduction of highly active antiretroviral therapy into practice, a significant decline of incidence of Kaposi's sarcoma is achieved.However, cases associated with late diagnosis of HIV infection continue to occur. We present clinical case of a patient with HIV infection with generalized Kaposi's sarcoma with multiple manifestations of lesions of the skin, mucous membranes and organs.If the diagnosis of lesions of the skin and mucous membranes did not cause difficulties, pulmonary lesions were difficult to be distinguished from disseminated tuberculosis, cytomegalovirus infection.The extremely severe course of the disease with an unfavorable outcome happened because of deep immunosuppression, and, apparently, manifestation of an inflammatory immune reconstitution syndrome.Autopsy, in addition to the skin and oral mucosal leasons foci in the epiglottis, larynx, trachea, lungs, colon, duodenum, peribronchial, mesenteric lymph nodes, liver, spleen, lumbar muscles were noted.Diagnosis of the internal organs involvement in Kaposi's sarcoma cases is not easy and requires the involvement of specialists in various fields.