Techniques of Gastroretentive Floating Drug Delivery Advancement A Review

The objective of preparing this article on gastroretentive floating drug delivery systems was to compile the recent literature with special focus on various gastroretentive approaches that have recently become leading methodologies in the field of site-specific orally administered controlled release drug delivery. Gastric emptying is a complex process and makes in vivo performance of the drug delivery systems uncertain. In order to understand various physiological difficulties to achieve gastric retention. In this article we have summarized important factors controlling gastric retention. Gastroretention would also facilitate local drug delivery to the stomach and proximal small intestine. So, gastroretention could help to provide greater availability of new as well as older generation products (5-FU) and consequently improved therapeutic activity with versatile clinical use and thus can provide required benefits to patients. In order to avoid various variability, efforts have been made to increase the retention time of the drug-delivery systems for more than 12 hours. The floating or hydrodynamically controlled drug delivery systems are useful in such application. From the formulation and technological point of view, the floating drug delivery system is comparatively easy and logical approach. The present review addresses briefly about the gastroretentive floating drug delivery systems . It also summarizes methods of evaluation of various floating dosage forms and applications of these systems.