两种基于人工神经网络的截尾数据离散生存时间建模

Taysseer Sharaf, C. Tsokos
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引用次数: 10

摘要

人工神经网络(ANN)理论作为传统统计方法在非线性函数建模方面的替代方法正在兴起。流行的Cox比例风险模型在模拟具有非线性行为的生存数据方面存在不足。由于不需要风险假设和模型松弛的比例性,人工神经网络是Cox PH的一个很好的替代方法。此外,人工神经网络具有处理与生存时间相关的危险因素之间复杂非线性关系的强大能力。在本研究中,我们全面比较了两种利用人工神经网络建模光滑条件风险概率函数的不同方法。我们使用真实的黑色素瘤癌症数据来说明所提出的人工神经网络方法的有效性。我们在比较男性和女性黑色素瘤患者的生存时间方面报告了一些显著的结果。
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Two Artificial Neural Networks for Modeling Discrete Survival Time of Censored Data
Artificial neural network (ANN) theory is emerging as an alternative to conventional statistical methods in modeling nonlinear functions. The popular Cox proportional hazard model falls short in modeling survival data with nonlinear behaviors. ANN is a good alternative to the Cox PH as the proportionality of the hazard assumption and model relaxations are not required. In addition, ANN possesses a powerful capability of handling complex nonlinear relations within the risk factors associated with survival time. In this study, we present a comprehensive comparison of two different approaches of utilizing ANN in modeling smooth conditional hazard probability function. We use real melanoma cancer data to illustrate the usefulness of the proposed ANN methods. We report some significant results in comparing the survival time of male and female melanoma patients.
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