吡唑啉酮类三齿席夫碱配体及其金属配合物的合成与抗菌研究

Organic Chemistry International Pub Date : 2010-12-26 DOI:10.1155/2010/648589

R. Jayarajan, G. Vasuki, P. S. Rao

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引用次数: 16

摘要

研究了含吡唑啉酮(3a和3b)的三齿希夫碱配体及其过渡金属VO(II)、Cu(II)、Fe(III)和Co(II) 4a-h配合物的合成、表征和抗菌活性。与配体相比，该配合物对金黄色葡萄球菌、大肠杆菌和伤寒葡萄球菌的抑菌活性增强，对白色念珠菌、根霉和黑曲霉的抑菌活性增强。

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Synthesis and Antimicrobial Studies of Tridentate Schiff Base Ligands with Pyrazolone Moiety and Their Metal Complexes

Synthesis, characterization, and antimicrobial activity of tridentate Schiffbase ligands containing pyrazolone moiety (3a and 3b) and their transition metal complexes of VO(II), Cu(II), Fe(III), and Co(II) 4a–h have been investigated. The complexes show enhanced antibacterial activity against S. aureus, E. coli, and S. typhi and antifungal activity against C. albicans, Rhizopus sp., and A. niger compared to the ligands.

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Organic Chemistry International

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