双相情感障碍孕妇的抗精神病药物和认知行为治疗

Kimberly Morton Cuthrell, M. Singh, Marly Villamar, Ushna Shabbir
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引用次数: 1

摘要

最困难的临床任务之一是治疗患有双相情感障碍的孕妇。患者和医生做出的决定是具有挑战性的,没有任何策略是没有风险的,也没有任何策略可以防止潜在的医疗事故诉讼。关于怀孕期间是否继续或停止使用抗精神病药物存在争议。虽然停用抗精神病药物可能会增加复发的风险,但继续使用这些药物可能会导致胎儿和母亲的不良后果。一些抗精神病药物有效地治疗双相情感障碍的相关症状,包括躁狂发作和躁狂与抑郁之间的情绪波动。虽然抗精神病药物可能对治疗和管理双相情感障碍有用,但这些药物并不总是有利的,并且与不良反应有关,这些不良反应影响了一些医疗专业人员几十年来实行防御性医疗,在某些情况下,可能与医学伦理一致或冲突。虽然抗精神病药物对孕妇双相情感障碍的影响不太安全但有效,但应考虑采用认知行为疗法(CBT)等替代治疗方法。CBT心理治疗是一种基于证据的实践方法,可以有益于治疗孕妇双相情感障碍,同时绕过抗精神病药物的相关不良反应。需要关注的是产前和产后抗精神病药物的使用及其相关的风险和益处,妊娠期间是否继续或停止抗精神病药物的争论,以及CBT在治疗双相情感障碍孕妇中的作用。虽然抗精神病药物可能具有不应强调的有益作用,但与妊娠期间使用抗精神病药物相关的风险不能最小化。
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Antipsychotic Medications and Cognitive Behavior Therapy in Pregnant Women with Bipolar Disorder
One of the most difficult clinical tasks is treating pregnant women with bipolar disorder. Decisions that patients and physicians make are challenging, and no strategy is without risks nor prevents potential malpractice litigation. There is debate about whether to continue or discontinue antipsychotic medications during pregnancy. While discontinuation of antipsychotics may increase the risk of relapse, continued use of these medications may lead to fetal and maternal adverse outcomes. Some antipsychotics effectively treat symptoms related to bipolar disorder, including manic episodes and mood swings between mania and depression. Though antipsychotics may be useful for the treatment and management of bipolar disorder, the medications are not always favorable and are associated with adverse effects which have influenced some medical professionals to practice defensive medicine for decades that, in some cases, may coincide or conflict with medical ethics. While antipsychotics have a less safe yet effective impact on bipolar disorder in pregnant women, an alternative therapeutic approach such as Cognitive Behavior Therapy (CBT) should be considered. CBT psychotherapy is an evidence-based practice approach that can be beneficial in the treatment of bipolar disorder in pregnant women while bypassing the associated adverse reactions of antipsychotics. Attention is needed to explore the use and associated risks and benefits of antipsychotic medications during prenatal and postnatal, the debate of whether to continue or discontinue antipsychotic medication during pregnancy, and the role of CBT in the treatment of pregnant women with bipolar disorder. While antipsychotics may have beneficial effects that should not be underscored, the risks associated with the usage of antipsychotics during pregnancy cannot be minimized.
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