新型抗毒药物氟噻嗪农的实验药代动力学、代谢及组织分布研究

Journal Biomed Pub Date : 2023-04-09 DOI:10.33647/2074-5982-19-1-73-84

M. V. Savitskii, N. Moskaleva, N. A. Zigangirova, A. Soloveva, A. Sheremet, N. Bondareva, N. L. Lubenec, N. V. Pyatigorskaya, S. Appolonova

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摘要

研究了新型抗毒药物氟噻嗪农(氟噻嗪农)在小鼠血液、肝脏、肾脏和肺中的药代动力学、组织利用度和代谢。氟噻嗪具有良好的组织利用度和较长的停留时间。这种药物主要通过葡萄糖醛酸化代谢。

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Experimental Pharmacokinetics, Metabolism and Tissue Distribution Studies Fluorothiazinon, a of Novel Antivirulence Drug

We studied the pharmacokinetics, tissue availability and metabolism of fluorothiazinon, a novel antivirulence drug, in mouse blood, liver, kidneys and lungs by administering the substance intragastrically at dose of 400 mg/kg. Fluorothiazinon was established to exhibit good tissue availability and long residential time. This drug is metabolized mainly by glucuronidation.

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Journal Biomed

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