前列腺癌的病理生物学:电压门控钠通道的表达和转移潜能

Şenay Yıldırım, S. P. Fraser, J. Diss, S. Altun, Anup Patel, M. Djamgoz
{"title":"前列腺癌的病理生物学:电压门控钠通道的表达和转移潜能","authors":"Şenay Yıldırım, S. P. Fraser, J. Diss, S. Altun, Anup Patel, M. Djamgoz","doi":"10.18478/IUFSJB.80034","DOIUrl":null,"url":null,"abstract":"Prostate cancer (PCa) remains the most frequently diagnosed cancer and the second most common cause of death from malignancy in men in the Western world. Despite this, conceptual advances in the understanding of its pathobiology have remained elusive for over half a century. As with all cancers, it is metastasis (i.e. secondary cancer formation) and its consequences that present the most significant biomedical and clinical challenges to the host, carers and healthcare payors, as well as the researchers. Pre-metastatic or metastataic PCa is frequently treated by hormone-based therapies aiming at androgen-down-regulation. However, this classic method is only effective for a limited time and new approaches are necessary (a) to improve the understanding of the pathobiology of PCa and (b) to develop new therapies for it, as well as improving the existing ones. In this article, we present an overview of the pathobiology of PCa and evaluate the evidence for the role of functional voltage-gated sodium channel (VGSC) expression in disease progression. We also discuss the possibility that VGSC blockers could be effective as novel anti-PCa drugs for clinical management of the metastatic phenotype.","PeriodicalId":14521,"journal":{"name":"IUFS Journal of Biology","volume":"10 1","pages":"1-17"},"PeriodicalIF":0.0000,"publicationDate":"2009-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"2","resultStr":"{\"title\":\"PATHOBIOLOGY OF PROSTATE CANCER:Voltage-gated sodium channel expression and metastatic potential\",\"authors\":\"Şenay Yıldırım, S. P. Fraser, J. Diss, S. Altun, Anup Patel, M. Djamgoz\",\"doi\":\"10.18478/IUFSJB.80034\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Prostate cancer (PCa) remains the most frequently diagnosed cancer and the second most common cause of death from malignancy in men in the Western world. Despite this, conceptual advances in the understanding of its pathobiology have remained elusive for over half a century. As with all cancers, it is metastasis (i.e. secondary cancer formation) and its consequences that present the most significant biomedical and clinical challenges to the host, carers and healthcare payors, as well as the researchers. Pre-metastatic or metastataic PCa is frequently treated by hormone-based therapies aiming at androgen-down-regulation. However, this classic method is only effective for a limited time and new approaches are necessary (a) to improve the understanding of the pathobiology of PCa and (b) to develop new therapies for it, as well as improving the existing ones. In this article, we present an overview of the pathobiology of PCa and evaluate the evidence for the role of functional voltage-gated sodium channel (VGSC) expression in disease progression. We also discuss the possibility that VGSC blockers could be effective as novel anti-PCa drugs for clinical management of the metastatic phenotype.\",\"PeriodicalId\":14521,\"journal\":{\"name\":\"IUFS Journal of Biology\",\"volume\":\"10 1\",\"pages\":\"1-17\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2009-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"2\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"IUFS Journal of Biology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.18478/IUFSJB.80034\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"IUFS Journal of Biology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.18478/IUFSJB.80034","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 2

摘要

在西方世界,前列腺癌仍然是最常被诊断的癌症,也是男性恶性肿瘤死亡的第二大常见原因。尽管如此,半个多世纪以来,对其病理生物学理解的概念性进展仍然难以捉摸。与所有癌症一样,转移(即继发性癌症形成)及其后果对宿主、护理人员和医疗保健支付者以及研究人员提出了最重大的生物医学和临床挑战。预转移性或转移性前列腺癌通常采用以雄激素下调为目标的激素治疗。然而,这种经典的方法只在有限的时间内有效,需要新的方法(a)提高对PCa病理生物学的认识,(b)开发新的治疗方法,并改进现有的治疗方法。在本文中,我们概述了前列腺癌的病理生物学,并评估了功能性电压门控钠通道(VGSC)表达在疾病进展中的作用的证据。我们还讨论了VGSC阻滞剂作为新型抗pca药物用于转移表型临床管理的可能性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
PATHOBIOLOGY OF PROSTATE CANCER:Voltage-gated sodium channel expression and metastatic potential
Prostate cancer (PCa) remains the most frequently diagnosed cancer and the second most common cause of death from malignancy in men in the Western world. Despite this, conceptual advances in the understanding of its pathobiology have remained elusive for over half a century. As with all cancers, it is metastasis (i.e. secondary cancer formation) and its consequences that present the most significant biomedical and clinical challenges to the host, carers and healthcare payors, as well as the researchers. Pre-metastatic or metastataic PCa is frequently treated by hormone-based therapies aiming at androgen-down-regulation. However, this classic method is only effective for a limited time and new approaches are necessary (a) to improve the understanding of the pathobiology of PCa and (b) to develop new therapies for it, as well as improving the existing ones. In this article, we present an overview of the pathobiology of PCa and evaluate the evidence for the role of functional voltage-gated sodium channel (VGSC) expression in disease progression. We also discuss the possibility that VGSC blockers could be effective as novel anti-PCa drugs for clinical management of the metastatic phenotype.
求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
自引率
0.00%
发文量
0
期刊最新文献
Lipoxygenase Inhibitory Activities of Some Plant Extracts and Chemical Compounds Three wheat cultivars’ responses to NaCl treatments: changes in lipid peroxidation, cell viability, hydrogen peroxide content and antioxidant defence parameters The role of Escherichia coli bacterioferritin in stressed induced conditions Phenolic composition and antibacterial activity of crude methanolic Calendula officinalis flower extract against plant pathogenic bacteria Scale Surface Microstructure and Scale Size in Three Mugilid Fishes (Teleostei, Mugilidae) of Iran from Three Different Habitats
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1