前列腺癌的病理生物学:电压门控钠通道的表达和转移潜能

Şenay Yıldırım, S. P. Fraser, J. Diss, S. Altun, Anup Patel, M. Djamgoz
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引用次数: 2

摘要

在西方世界,前列腺癌仍然是最常被诊断的癌症,也是男性恶性肿瘤死亡的第二大常见原因。尽管如此,半个多世纪以来,对其病理生物学理解的概念性进展仍然难以捉摸。与所有癌症一样,转移(即继发性癌症形成)及其后果对宿主、护理人员和医疗保健支付者以及研究人员提出了最重大的生物医学和临床挑战。预转移性或转移性前列腺癌通常采用以雄激素下调为目标的激素治疗。然而,这种经典的方法只在有限的时间内有效,需要新的方法(a)提高对PCa病理生物学的认识,(b)开发新的治疗方法,并改进现有的治疗方法。在本文中,我们概述了前列腺癌的病理生物学,并评估了功能性电压门控钠通道(VGSC)表达在疾病进展中的作用的证据。我们还讨论了VGSC阻滞剂作为新型抗pca药物用于转移表型临床管理的可能性。
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PATHOBIOLOGY OF PROSTATE CANCER:Voltage-gated sodium channel expression and metastatic potential
Prostate cancer (PCa) remains the most frequently diagnosed cancer and the second most common cause of death from malignancy in men in the Western world. Despite this, conceptual advances in the understanding of its pathobiology have remained elusive for over half a century. As with all cancers, it is metastasis (i.e. secondary cancer formation) and its consequences that present the most significant biomedical and clinical challenges to the host, carers and healthcare payors, as well as the researchers. Pre-metastatic or metastataic PCa is frequently treated by hormone-based therapies aiming at androgen-down-regulation. However, this classic method is only effective for a limited time and new approaches are necessary (a) to improve the understanding of the pathobiology of PCa and (b) to develop new therapies for it, as well as improving the existing ones. In this article, we present an overview of the pathobiology of PCa and evaluate the evidence for the role of functional voltage-gated sodium channel (VGSC) expression in disease progression. We also discuss the possibility that VGSC blockers could be effective as novel anti-PCa drugs for clinical management of the metastatic phenotype.
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