Noureddine Hamou Ahabchane , Sanae Ibrahimi , Moussa Salem , El Mokhtar Essassi , Saaid Amzazi , Abdelaziz Benjouad
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引用次数: 1
摘要
二硫化碳在3(5)- n -〚甲基(乙基)-2-氨基苯基氨基-5(3)-苯基吡唑3(4)上加成，得到10-甲基(乙基)-3-苯基吡唑〚4,3-c〚1,5苯二氮卓-4-硫酮7(8)。这些化合物与烷基卤化物和乙酰肼或苯甲酰肼反应，得到新的杂环体系:pyrazolo〚4,3-c三唑〚4,3-a -1,5-苯二氮卓15-18。化合物8、9、16和17的生物学性质已被评价。
Synthèse et propriétés biologiques des pyrazolo〚4,3-c〛triazolo〚4,3-a〛〚1,5〛benzodiazépines
The addition of carbon disulfide to 3(5)-N-〚methyl (ethyl)-2-aminophenyl amino-5(3)-phenylpyrazole 3 (4) afforded 10-methyl (ethyl)-3-phenylpyrazolo〚4,3-c〛 〚1,5〛 benzodiazepine-4-thione 7 (8). These compounds reacted with alkyl halides and acetylhydrazide or benzoylhydrazide, to afford new heterocyclic systems: pyrazolo 〚4,3-c〛 triazolo〚4,3-a〛-1,5-benzodiazepines 15–18. Biological properties of compounds 8, 9, 16 and 17 have been evaluated.
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