{"title":"血管紧张素转换酶抑制剂和血管紧张素II受体拮抗剂对腹膜透析患者残余肾功能保存的影响","authors":"Reyes Marin Fernando Arturo","doi":"10.32474/JUNS.2018.01.000117","DOIUrl":null,"url":null,"abstract":"Angiotensin-converting enzyme inhibitors (ACEi) and angiotensin II receptor blockers (ARBs) are recommended in peritoneal dialysis (PD) patients for hypertension or heart failure control [1] Angiotensin II (AII) is an important factor in the development of renal fibrosis due to its hemodynamic effects on glomeruli and stimulation of extracellular matrix proteins synthesis, mediated by TGF b [2]. This may explain why treatment with ACEi and ARBs is renoprotective in patients with diabetic and non-diabetic nephropathy.","PeriodicalId":17651,"journal":{"name":"Journal of Urology & Nephrology Studies","volume":"22 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2019-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Angiotensin Converting Enzyme Inhibitors and Angiotensin II Receptor Antagonists on Residual Renal Function Preservation in Peritoneal Dialysis Patients\",\"authors\":\"Reyes Marin Fernando Arturo\",\"doi\":\"10.32474/JUNS.2018.01.000117\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Angiotensin-converting enzyme inhibitors (ACEi) and angiotensin II receptor blockers (ARBs) are recommended in peritoneal dialysis (PD) patients for hypertension or heart failure control [1] Angiotensin II (AII) is an important factor in the development of renal fibrosis due to its hemodynamic effects on glomeruli and stimulation of extracellular matrix proteins synthesis, mediated by TGF b [2]. This may explain why treatment with ACEi and ARBs is renoprotective in patients with diabetic and non-diabetic nephropathy.\",\"PeriodicalId\":17651,\"journal\":{\"name\":\"Journal of Urology & Nephrology Studies\",\"volume\":\"22 1\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2019-01-24\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Urology & Nephrology Studies\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.32474/JUNS.2018.01.000117\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Urology & Nephrology Studies","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.32474/JUNS.2018.01.000117","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
摘要
血管紧张素转换酶抑制剂(angiotensin -converting enzyme inhibitors, ACEi)和血管紧张素受体阻滞剂(angiotensin II receptor blockers, ARBs)被推荐用于腹膜透析(PD)患者的高血压或心力衰竭控制[1]。血管紧张素II (angiotensin II, AII)通过TGF b介导对肾小球的血流动力学作用和刺激细胞外基质蛋白合成，是肾纤维化发生的重要因素[2]。这也许可以解释为什么ACEi和ARBs治疗对糖尿病和非糖尿病肾病患者具有肾保护作用。
Angiotensin Converting Enzyme Inhibitors and Angiotensin II Receptor Antagonists on Residual Renal Function Preservation in Peritoneal Dialysis Patients
Angiotensin-converting enzyme inhibitors (ACEi) and angiotensin II receptor blockers (ARBs) are recommended in peritoneal dialysis (PD) patients for hypertension or heart failure control [1] Angiotensin II (AII) is an important factor in the development of renal fibrosis due to its hemodynamic effects on glomeruli and stimulation of extracellular matrix proteins synthesis, mediated by TGF b [2]. This may explain why treatment with ACEi and ARBs is renoprotective in patients with diabetic and non-diabetic nephropathy.
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