{"title":"小鼠细胞色素c氧化酶亚基VIIaL基因的鉴定","authors":"Karine Chantrel-Groussard , Laurent Delpy , Marie-Hélène Ratinaud , Michel Cogné","doi":"10.1016/S0764-4469(01)01398-1","DOIUrl":null,"url":null,"abstract":"<div><p>Mammalian cytochrome <em>c</em> oxidase consists of thirteen subunits, ten encoded by the nuclear genome and three by the mitochondrial DNA. In several species, two isoforms have been isolated for nuclear-encoded subunits VIa, VIIa and VIII : an ubiquitous L (liver) form and a heart- and skeletal-muscle specific H form. The gene for murine cytochrome <em>c</em> oxidase subunit VIIa-L (<em>Cox7aL</em>) and its promoter region were isolated, sequenced and analysed. The coding region is split in four exons spanning 4.1 kbp and the promoter carries potential binding sites for Sp1, NRF1 and NRF2 transcription factors. Transcriptional activity of the promoter in reporter assays suggested an ubiquitous expression in mouse tissues.</p></div>","PeriodicalId":100306,"journal":{"name":"Comptes Rendus de l'Académie des Sciences - Series III - Sciences de la Vie","volume":"324 12","pages":"Pages 1117-1123"},"PeriodicalIF":0.0000,"publicationDate":"2001-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0764-4469(01)01398-1","citationCount":"3","resultStr":"{\"title\":\"Characterization of the murine gene for subunit VIIaL of cytochrome c oxidase\",\"authors\":\"Karine Chantrel-Groussard , Laurent Delpy , Marie-Hélène Ratinaud , Michel Cogné\",\"doi\":\"10.1016/S0764-4469(01)01398-1\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Mammalian cytochrome <em>c</em> oxidase consists of thirteen subunits, ten encoded by the nuclear genome and three by the mitochondrial DNA. In several species, two isoforms have been isolated for nuclear-encoded subunits VIa, VIIa and VIII : an ubiquitous L (liver) form and a heart- and skeletal-muscle specific H form. The gene for murine cytochrome <em>c</em> oxidase subunit VIIa-L (<em>Cox7aL</em>) and its promoter region were isolated, sequenced and analysed. The coding region is split in four exons spanning 4.1 kbp and the promoter carries potential binding sites for Sp1, NRF1 and NRF2 transcription factors. Transcriptional activity of the promoter in reporter assays suggested an ubiquitous expression in mouse tissues.</p></div>\",\"PeriodicalId\":100306,\"journal\":{\"name\":\"Comptes Rendus de l'Académie des Sciences - Series III - Sciences de la Vie\",\"volume\":\"324 12\",\"pages\":\"Pages 1117-1123\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2001-12-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/S0764-4469(01)01398-1\",\"citationCount\":\"3\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Comptes Rendus de l'Académie des Sciences - Series III - Sciences de la Vie\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0764446901013981\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Comptes Rendus de l'Académie des Sciences - Series III - Sciences de la Vie","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0764446901013981","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Characterization of the murine gene for subunit VIIaL of cytochrome c oxidase
Mammalian cytochrome c oxidase consists of thirteen subunits, ten encoded by the nuclear genome and three by the mitochondrial DNA. In several species, two isoforms have been isolated for nuclear-encoded subunits VIa, VIIa and VIII : an ubiquitous L (liver) form and a heart- and skeletal-muscle specific H form. The gene for murine cytochrome c oxidase subunit VIIa-L (Cox7aL) and its promoter region were isolated, sequenced and analysed. The coding region is split in four exons spanning 4.1 kbp and the promoter carries potential binding sites for Sp1, NRF1 and NRF2 transcription factors. Transcriptional activity of the promoter in reporter assays suggested an ubiquitous expression in mouse tissues.
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