抗癌药物生物等效性及生物利用度研究综述

Behera A
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引用次数: 0

摘要

生物利用度一直是制剂是否有效的最重要的特性之一。一些抗癌药物的口服生物利用度和溶解度较差,这对世界各地的科学家提出了挑战,要求他们与传统的给药系统进行不同的思考。近年来,为了提高这些药物的生物利用度,越来越多地使用天然聚合物。酪蛋白聚合物具有两亲性,可结合亲水和疏水药物,在提高抗癌药物的生物利用度方面具有广阔的应用前景。由于酪蛋白的性质,它引起了全世界科学家的注意。在这篇综述中,我们重点介绍了各种科学家在提高生物利用度差的抗癌药物的口服生物利用度方面的工作。
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A Mini Review on Bioequivalence & the Bioavailability Study on Anticancer Drugs
Bioavailability has been one of the most important properties for the formulation to be an effective. The poor oral bioavailability and solubility of several anti-cancer drugs has challenged the scientists all over the world to think differently than the traditional drug delivery system. Recently, the use of natural polymer has been increased to increase the bioavailability of these drugs. Casein polymer has shown to be promising in increasing the bioavailability of the anticancer drugs due to its amphiphilic nature which can bind both hydrophilic and hydrophobic drugs. Due to the nature of the casein it has drawn the attention of the scientists all over the world. In this review, we have focused on the work of various scientists in increasing the oral bioavailability of poorly bioavailable anticancer drugs.
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