使用Block II化学生物质谱仪对生物制剂进行检测和鉴定

Field Analytical Chemistry and Technology Pub Date : 2001-01-01 DOI:10.1002/FACT.1019

W. Griest, M. Wise, K. J. Hart, S. A. Lammert, C. V. Thompson, A. Vass

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引用次数: 28

摘要

Block II化学生物质谱仪(CBMS)检测和识别化学和生物战剂。生物检测的基础是通过反向喷射虚拟撞击器收集可吸入颗粒，通过热裂解甲基化释放衍生生物标志物，并在全扫描化学电离模式下通过直接采样离子阱质谱法进行分析。实验室和现场试验的结果表明，Block II CBMS具有生物检测和鉴定的能力。©2001 John Wiley & Sons, Inc.Field analyst Chem technology 5: 177-184, 2001

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Biological agent detection and identification by the Block II Chemical Biological Mass Spectrometer

The Block II Chemical Biological Mass Spectrometer (CBMS) detects and identifies both chemical and biological warfare agents. Biodetection is based upon respirable particle collection by an opposed-jet virtual impactor, liberation of derivatized biomarkers by thermolysis-methylation and their analysis by direct-sampling ion trap mass spectrometry in the full-scan chemical ionization mode. Results from laboratory and field trials demonstrate the capability of the Block II CBMS for biodetection and identification. © 2001 John Wiley & Sons, Inc.Field Analyt Chem Technol 5: 177–184, 2001

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Field Analytical Chemistry and Technology

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