Klotho 与神经精神障碍的关系:元分析

IF 0.9 Q2 LINGUISTICS Australian Review of Applied Linguistics Pub Date : 2024-07-01 Epub Date: 2023-03-31 DOI:10.1007/s12291-023-01132-5
Amandeep Birdi, Sojit Tomo, Monika Sharma, Pankaj Yadav, Jaykaran Charan, Praveen Sharma, Dharmveer Yadav
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引用次数: 0

摘要

神经精神疾病主要与行为、情绪和认知症状有关,这些症状可能是由于大脑功能紊乱或脑外疾病引起的。Klotho 蛋白是一种抗衰老蛋白,它与这些疾病中的认知变化有很大关系,因此本荟萃分析旨在发现 Klotho 蛋白与这些疾病的关系。我们在 Pubmed 上搜索了相关主题,使用的关键词是 Klotho 和神经精神科的相关疾病,如 Klotho 水平与精神分裂症、Klotho 水平与帕金森病等。经过广泛搜索,截至 2021 年 2 月 9 日共找到 82 项研究,并选择了 10 项研究进行进一步分析。研究的荟萃分析采用随机效应模型。森林图代表了荟萃分析中的每项研究,以便对不同研究的 SMD 值进行比较。荟萃分析结果表明,与双相情感障碍、社会心理压力、帕金森氏症、多发性硬化症、抑郁症、阿尔茨海默病和健康对照组相比,精神分裂症的总体 klotho 水平较高,其次是多发性硬化症。荟萃分析还发现,与精神分裂症相比,双相情感障碍和阿尔茨海默病的 klotho 水平较低。结果表明,klotho水平与精神分裂症有明显的关联。要确定 klotho 水平在精神疾病中的潜在生物学作用,还需要进一步的研究。
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Association of Klotho with Neuropsychiatric Disorder: A Meta-Analysis.

Neuropsychiatric disorders are mainly concerned with the behavioural, emotional and cognition symptoms that may be due to disturbed cerebral functions or extracerebral disease. Klotho protein is an antiaging protein that is mostly associated with cognitive changes in these disorders and thus this meta-analysis is conducted in order to find Klotho proteins association with these disorders. We searched related topics in pubmed, by using the key word i.e. Klotho and related disorder from neuropsychiatry e.g. Klotho levels and schizophrenia, Klotho levels and parkinsonism etc. Total 82 studies were found till 9th February 2021 after extensive search and 10 studies were selected for further analysis. The meta-analysis of studies was performed using the Random effect model. The forest plot represented each study in the meta-analysis, so as to make the comparison of SMD value across studies. The meta-analysis outcome demonstrated that overall schizophrenia had higher klotho levels as compared with bipolar disorder, psychosocial stress, parkinsonism, multiple sclerosis, depression, Alzheimer's disease, and healthy controls, followed by MS. The meta-analysis also found that bipolar disorder and Alzheimer's disease were associated with low klotho levels as compared to schizophrenia. The results indicate a significant association of the klotho levels and schizophrenia. Further studies are needed to characterize the potential biological roles of klotho levels in psychiatric disorders.

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来源期刊
CiteScore
2.70
自引率
8.30%
发文量
24
期刊介绍: The Australian Review of Applied Linguistics (ARAL) is the preeminent journal of the Applied Linguistics Association of Australia (ALAA). ARAL is a peer reviewed journal that promotes scholarly discussion and contemporary understandings of language-related matters with a view to impacting on real-world problems and debates. The journal publishes empirical and theoretical research on language/s in educational, professional, institutional and community settings. ARAL welcomes national and international submissions presenting research related to any of the major sub-disciplines of Applied Linguistics as well as transdisciplinary studies. Areas of particular interest include but are not limited to: · Analysis of discourse and interaction · Assessment and evaluation · Bi/multilingualism and bi/multilingual education · Corpus linguistics · Cognitive linguistics · Language, culture and identity · Language maintenance and revitalization · Language planning and policy · Language teaching and learning, including specific languages and TESOL · Pragmatics · Research design and methodology · Second language acquisition · Sociolinguistics · Language and technology · Translating and interpreting.
期刊最新文献
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