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Association of Klotho with Neuropsychiatric Disorder: A Meta-Analysis. Klotho 与神经精神障碍的关系:元分析
IF 1.5 Q2 LINGUISTICS Pub Date : 2024-07-01 Epub Date: 2023-03-31 DOI: 10.1007/s12291-023-01132-5
Amandeep Birdi, Sojit Tomo, Monika Sharma, Pankaj Yadav, Jaykaran Charan, Praveen Sharma, Dharmveer Yadav

Neuropsychiatric disorders are mainly concerned with the behavioural, emotional and cognition symptoms that may be due to disturbed cerebral functions or extracerebral disease. Klotho protein is an antiaging protein that is mostly associated with cognitive changes in these disorders and thus this meta-analysis is conducted in order to find Klotho proteins association with these disorders. We searched related topics in pubmed, by using the key word i.e. Klotho and related disorder from neuropsychiatry e.g. Klotho levels and schizophrenia, Klotho levels and parkinsonism etc. Total 82 studies were found till 9th February 2021 after extensive search and 10 studies were selected for further analysis. The meta-analysis of studies was performed using the Random effect model. The forest plot represented each study in the meta-analysis, so as to make the comparison of SMD value across studies. The meta-analysis outcome demonstrated that overall schizophrenia had higher klotho levels as compared with bipolar disorder, psychosocial stress, parkinsonism, multiple sclerosis, depression, Alzheimer's disease, and healthy controls, followed by MS. The meta-analysis also found that bipolar disorder and Alzheimer's disease were associated with low klotho levels as compared to schizophrenia. The results indicate a significant association of the klotho levels and schizophrenia. Further studies are needed to characterize the potential biological roles of klotho levels in psychiatric disorders.

神经精神疾病主要与行为、情绪和认知症状有关,这些症状可能是由于大脑功能紊乱或脑外疾病引起的。Klotho 蛋白是一种抗衰老蛋白,它与这些疾病中的认知变化有很大关系,因此本荟萃分析旨在发现 Klotho 蛋白与这些疾病的关系。我们在 Pubmed 上搜索了相关主题,使用的关键词是 Klotho 和神经精神科的相关疾病,如 Klotho 水平与精神分裂症、Klotho 水平与帕金森病等。经过广泛搜索,截至 2021 年 2 月 9 日共找到 82 项研究,并选择了 10 项研究进行进一步分析。研究的荟萃分析采用随机效应模型。森林图代表了荟萃分析中的每项研究,以便对不同研究的 SMD 值进行比较。荟萃分析结果表明,与双相情感障碍、社会心理压力、帕金森氏症、多发性硬化症、抑郁症、阿尔茨海默病和健康对照组相比,精神分裂症的总体 klotho 水平较高,其次是多发性硬化症。荟萃分析还发现,与精神分裂症相比,双相情感障碍和阿尔茨海默病的 klotho 水平较低。结果表明,klotho水平与精神分裂症有明显的关联。要确定 klotho 水平在精神疾病中的潜在生物学作用,还需要进一步的研究。
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引用次数: 0
Experiences of supporting adults with literacy gaps 为存在识字差距的成人提供支持的经验
IF 1.2 Q2 LINGUISTICS Pub Date : 2023-12-21 DOI: 10.1075/aral.23015.bla
Sebastian J. Blake
This paper uses a thematic narrative analysis approach to explore the experiences of individuals who support those living with literacy gaps in Australia. Themes of collective shame and responsibility surrounding adult literacy gaps, as well as the communicative expertise and critical reflexivity developed by supporters in their roles, are prominent in their narratives. As part of a more extensive study that also explored the experiences of people living with literacy gaps, the findings of this paper highlight the need for more research into this area, particularly underscoring the importance of including first-hand accounts from those directly impacted by literacy gaps and recognizing adult literacy supporters as a unique population.
本文采用主题叙事分析方法,探讨了澳大利亚为存在识字差距的人提供支持的个人经历。在他们的叙述中,围绕成人扫盲差距的集体羞耻感和责任感,以及支持者在其角色中发展起来的沟通专长和批判性反思能力等主题十分突出。作为一项更广泛研究的一部分,该研究还探讨了存在识字差距的人的经历,本文的研究结果强调了在这一领域开展更多研究的必要性,特别强调了纳入直接受识字差距影响的人的第一手叙述的重要性,并认识到成人扫盲支持者是一个独特的群体。
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引用次数: 0
Teaching culture in a competitive market 竞争激烈的市场中的教学文化
IF 1.2 Q2 LINGUISTICS Pub Date : 2023-12-14 DOI: 10.1075/aral.22019.ben
Jonathan Benney, Philip Wing Keung Chan, Maria Gindidis
In 2012, the White Paper Australia in the Asian Century urged governments across Australia to improve access to Asian studies in schools. Despite this, schools still struggle to maintain interest and success for secondary students, particularly those without an Asian family background. In response to the low numbers of non-Chinese-background students graduating from secondary schools with proficiency in Chinese language, the Victorian government launched a new Chinese Language, Culture, and Society subject in 2017. This study focuses on the teaching of this subject, which is taken in the last two years of secondary schooling during the pre-tertiary Victorian Certificate of Education (VCE). Drawing upon interview data with administrators, teachers and students during the first years of its implementation, the article presents the views and challenges of stakeholders involved in this subject and argues that the inherent limitations of the VCE system will make it difficult for the new subject to achieve its stated aims.
2012年,《亚洲世纪中的澳大利亚》白皮书敦促澳大利亚各地政府改善学校的亚洲研究。尽管如此,学校仍在努力保持中学生的学习兴趣和成功率,尤其是那些没有亚裔家庭背景的学生。针对中学非华裔背景学生毕业时中文水平较低的情况,维多利亚州政府于2017年推出了新的 "中国语言、文化与社会 "科目。本研究的重点是该科目的教学情况,该科目在中学最后两年的维多利亚州教育证书(VCE)预科中学习。文章通过对该科目实施前几年的管理人员、教师和学生的访谈资料,介绍了参与该科目的利益相关者的观点和挑战,并认为维多利亚州教育证书制度的固有局限性将使新科目难以实现其既定目标。
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引用次数: 0
First and second language speakers’ sensitivity to the distributional properties of wh-clauses 第一语言和第二语言使用者对 wh-clauses 分布特性的敏感性
IF 1.2 Q2 LINGUISTICS Pub Date : 2023-12-08 DOI: 10.1075/aral.23011.dom
Ivana Domazetoska, Helen Zhao
The present study investigates L1 and L2 English speakers’ knowledge of the wh-clausal construction along the parameters of (a) conventionality, distinguishing between high-frequency conventional and low-frequency unconventional formulations (I asked him why they agreed/why did they agree), and (b) proposition type, differentiating between interrogative versus non-interrogative proposition types (I asked / told him why they agreed). We also consider the extent to which L2 speakers’ constructional knowledge is influenced by learners’ target language experience, such as L2 proficiency, context of L2 learning (ESL or EFL), and target language exposure. Results from a judgment task revealed nuances in L1-L2 discriminatory capacities, and more importantly, differences in sensitivity to proposition type between the ESL and EFL group, but no L2 differences in sensitivity to conventionality. L2 proficiency, speakers’ length of target immersion experience, and classroom exposure were shown to also impact linguistic sensitivity, highlighting a moderating effect of target language exposure and an important role for classroom instruction.
本研究调查了母语和第二语言的英语使用者对wh-小句结构的了解,这些知识包括:(a)规定性,区分高频规定性和低频非常规规定性(我问他为什么他们同意/为什么他们同意),以及(b)命题类型,区分疑问句和非疑问句命题类型(我问/告诉他为什么他们同意)。我们还考虑了二语使用者的结构知识在多大程度上受到学习者目标语言经验的影响,如二语熟练程度、二语学习环境(ESL或EFL)和目标语言暴露。一项判断任务的结果显示,第二语言组和第二语言组的区分能力存在细微差别,更重要的是,第二语言组对命题类型的敏感性存在差异,但对惯例的敏感性没有差异。第二语言熟练程度、说话者的目标语沉浸体验时长和课堂曝光也会影响语言敏感性,这突出了目标语曝光的调节作用和课堂教学的重要作用。
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引用次数: 0
Evaluating stakeholders in information for parents of children who are deaf or hard-of-hearing 为失聪或听力障碍儿童的父母评估信息的利益相关者
Q2 LINGUISTICS Pub Date : 2023-10-23 DOI: 10.1075/aral.22036.kec
Emily Kecman, John S. Knox
Abstract Parents of children who are deaf or hard-of-hearing (D/HH) need clear and complete information about early intervention options. There is a body of research on parents’ reactions to, and perceptions of, information they encountered following their child’s diagnosis, but little research examining the information itself. This paper reports on a research project examining the evaluative meanings of information on the websites of the two early intervention providers in NSW, Australia. Both providers describe their services as “family-centered” on their websites. The appraisal framework from systemic functional linguistics was used to analyze each website. Specifically, evaluations regarding the ‘capacity’ of providers and D/HH children are reported here. Providers are consistently evaluated as altruistic and expert, while D/HH children are consistently evaluated as requiring the specific kind of intervention program offered by these organizations in order to live a “normal” or “successful” life. Coupled with the lack of information about alternative approaches to early intervention, the information provided appears to be inconsistent with principles of family-centered intervention.
失聪或听力障碍儿童(D/HH)的父母需要关于早期干预选择的明确和完整的信息。有大量的研究是关于父母在孩子诊断后对信息的反应和感知,但很少有研究是针对信息本身的。本文报告了一项研究项目,研究了澳大利亚新南威尔士州两家早期干预提供者网站上信息的评估意义。两家供应商都在其网站上描述他们的服务是“以家庭为中心”的。采用系统功能语言学的评价框架对各网站进行分析。具体地说,这里报告了关于提供者和D/HH儿童“能力”的评估。提供者一直被评价为无私和专家,而D/HH儿童一直被评价为需要这些组织提供的特定类型的干预计划,以便过上“正常”或“成功”的生活。再加上缺乏关于早期干预的替代办法的资料,所提供的资料似乎与以家庭为中心的干预原则不一致。
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引用次数: 0
Rethinking self, presence, and participation in online teaching and learning during the COVID-19 pandemic 在2019冠状病毒病大流行期间,重新思考在线教学的自我、存在和参与
Q2 LINGUISTICS Pub Date : 2023-09-21 DOI: 10.1075/aral.23008.one
Fiona O’Neill, Timothy James McGrath
Abstract The shift to online learning during the COVID-19 pandemic has been a learning experience for educators. While online learning is not new, the sudden loss of familiar cues has highlighted challenges for learners and teachers. This paper focuses on the significance of language in virtual classrooms in an Australian university in the narrative accounts elicited from five educators. The analysis drew on notions of activity types ( Levinson, 1979 ), the dramaturgic self ( Goffman, 1959 ), and learning as a reciprocal, meaning-making, and interpretive process ( Scarino, 2014 ). The findings demonstrate that the participants responded to the challenges and possibilities they encountered by developing ways of rethinking self, presence, and participation in interaction with learners. We argue that this process involves an intercultural orientation to teaching and learning in online settings that is key to reflective practice, relationships of trust and shared understandings in teaching, learning, and knowing, well beyond the pandemic.
COVID-19大流行期间向在线学习的转变对教育工作者来说是一次学习经历。虽然在线学习并不新鲜,但突然失去熟悉的线索对学习者和教师来说都是一个突出的挑战。本文从五位教育工作者的叙述中探讨了语言在澳大利亚大学虚拟课堂中的重要性。该分析借鉴了活动类型(Levinson, 1979)、戏剧自我(Goffman, 1959)和学习作为一个相互的、意义创造和解释过程(Scarino, 2014)的概念。研究结果表明,参与者通过发展重新思考自我、存在和参与与学习者互动的方式来应对他们遇到的挑战和可能性。我们认为,这一过程涉及在线教学和学习的跨文化取向,这是反思性实践、信任关系和教学、学习和知识共享理解的关键,远远超出了疫情范围。
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引用次数: 0
Language learning for language minority students in a globalized world 全球化背景下少数民族学生的语言学习
Q2 LINGUISTICS Pub Date : 2023-09-14 DOI: 10.1075/aral.00042.ten
Mark Feng Teng, Fan Fang
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引用次数: 0
Applied semantics and climate communication 应用语义学与气候通信
IF 1.2 Q2 LINGUISTICS Pub Date : 2023-07-27 DOI: 10.1075/aral.22028.bro
H. Bromhead, C. Goddard
This paper explores ways in which applied semantics (coming out of Natural Semantic Metalanguage approach) can inform effective communicative strategies for action on climate change. After framing discussion, it presents three case studies, which are intentionally disparate in nature: contrastive semantics of the expressions ‘climate crisis’, ‘climate emergency’, and ‘climate catastrophe’; a semantically-enhanced examination of how public inquiries into extreme weather events help shape climate discourse in Australia; the semantics of ‘the economy’ in everyday English and the implications for climate change discourse. We argue that climate action communication is clearer, more resonant, and more effective when it uses or builds on ordinary words and local meanings.
本文探讨了应用语义(源于自然语义元语言方法)如何为应对气候变化的有效沟通策略提供信息。在框架讨论之后,它提出了三个在性质上有意不同的案例研究:“气候危机”、“气候紧急情况”和“气候灾难”的对比语义;对公众对极端天气事件的调查如何帮助塑造澳大利亚的气候话语进行语义强化的研究;日常英语中“经济”的语义以及对气候变化话语的影响。我们认为,当气候行动沟通使用或建立在普通词语和当地含义的基础上时,它更清晰、更具共鸣性、更有效。
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引用次数: 0
A socio-psychological analysis of goal-setting when deciding to learn a second language 决定学习第二语言时目标设定的社会心理学分析
IF 1.2 Q2 LINGUISTICS Pub Date : 2023-07-20 DOI: 10.1075/aral.21070.dor
Giuseppe D’Orazzi
This study bridges a gap in the current research on motivation and demotivation learning a second language (L2). It is meant to provide an overview of students’ goal setting when they start to learn an L2 at university level in Australia. Drawing on goal-setting and learning goal orientation constructs (cf. Miller, 2020), goal formation is deconstructed and analysed to throw new light on students’ psychological processes identified at the micro level and the influences on goal setting stemming from the social context at the macro level in which students operate. The interaction between the two levels is explored in order to understand which dynamics lie behind research participants’ desire of gaining proficiency in French, German, Italian, and Spanish. Qualitative data analysis outcomes are shown in an attempt to provide clear and applicable pedagogical suggestions for L2 practitioners (see, e.g., Al-Hoorie et al., 2021).
本研究填补了当前关于第二语言学习动机和动机缺失研究的空白。它旨在提供学生在澳大利亚大学开始学习第二语言时目标设定的概述。利用目标设定和学习目标导向结构(cf. Miller, 2020),对目标形成进行了解构和分析,从而在微观层面上揭示了学生的心理过程,在宏观层面上揭示了学生所处的社会环境对目标设定的影响。为了了解研究参与者渴望熟练掌握法语、德语、意大利语和西班牙语背后的动力,研究人员探索了这两个层次之间的相互作用。定性数据分析结果的展示是为了为第二语言从业者提供明确和适用的教学建议(参见al - hoorie等人,2021)。
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引用次数: 0
Reflections on language learning and social practice for language minority students 少数民族学生语言学习与社会实践的思考
IF 1.2 Q2 LINGUISTICS Pub Date : 2023-07-17 DOI: 10.1075/aral.00043.lid
A. Liddicoat
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引用次数: 0
期刊
Australian Review of Applied Linguistics
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