嗅觉刺激控制与记忆的行为药理学。

M. Galizio
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引用次数: 7

摘要

行为分析的方法和技术对记忆的研究有很大的帮助。目前,人们对人类记忆过程的动物模型的发展非常感兴趣,以增强对记忆的神经生物学的理解,以及对痴呆症和相关疾病的治疗。由于啮齿动物模型在当代神经科学和遗传学中如此重要,因此研究啮齿动物各种形式记忆的程序的发展是一个重点。嗅觉在啮齿动物的行为中扮演着重要的角色,嗅觉刺激的使用已经证明了复杂形式的刺激控制,这也为研究药物对记忆的影响提供了基础。本文主要研究了药物对两种相关程序维持的行为的影响:气味与样本的延迟匹配和气味跨度任务。这些类型的程序为探索药物对多种刺激和一系列延迟间隔维持的行为的影响提供了机会,并有可能推进记忆的行为药理学分析。
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Olfactory Stimulus Control and the Behavioral Pharmacology of Remembering.
Behavior analytic approaches and techniques have much to offer to the study of remembering. There is currently great interest in the development of animal models of human memory processes in order to enhance understanding of the neurobiology of memory and treatment of dementia and related disorders. Because rodent models are so important in contemporary neuroscience and genetics, development of procedures to study various forms of memory in rodents is a point of emphasis. The sense of smell plays an important role in rodent behavior and use of olfactory stimuli has permitted demonstrations of complex forms of stimulus control that have also served as baselines for studying drug effects on remembering. This article focuses on the effects of drugs on behavior maintained by two related procedures: delayed matching-to-sample with odors and the Odor Span Task. These types of procedures provide an opportunity to explore drug effects on behavior maintained by multiple stimuli and across a range of delay intervals with potential to advance analysis of the behavioral pharmacology of remembering.
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