Cobalt-Catalyzed Enantioselective Alkynylation of Oxabicyclic Alkenes

An efficient access to enantioenriched cyclic homopropargylic alcohols through an unprecedented cobalt-catalyzed asymmetric alkynylation of oxabicyclic alkenes. By using inexpensive cobalt salt/chiral bisphosphine ligand as the catalyst and easy-to-handle potassium alkynyltrifluoroborates as the nucleophiles, synthetically valuable homopropargylic alcohols are obtained in moderate to good yields and high enantioselectivities.