{"title":"最优控制下动物和人类李斯特菌病流行的数学模型。","authors":"Shaibu Osman, O. Makinde, D. Theuri","doi":"10.5556/j.tkjm.51.2020.2860","DOIUrl":null,"url":null,"abstract":"Listeriosis is a serious disease caused by the germ Listeria monocytogenes. People usually become ill with listeriosis after eating contaminated food including meat. The disease primarily affects pregnant women, newborns, older adults, and people with weakened immune systems. In this paper, we propose and scrutinize a model problem describing the transmission dynamics of Listeriosis epidemic in animal and human population using the stability theory of differential equations. The model is qualitatively analysed for the basic reproduction number as well as possibility of forward and backward bifurcation with respect to the stability of disease free and endemic equilibria. The impact of the model parameters on the disease was evaluated via sensitivity analysis. An extension of the model to include time dependent control variables such as treatment, vaccination and education of susceptible (human) is carried out. Using Pontryagin’s Maximum Principle, we obtain the optimal control strategies needed for combating Listeriosis disease. Numerical simulation of the model is performed and pertinent results are displayed graphically and discussed quantitatively.","PeriodicalId":45776,"journal":{"name":"Tamkang Journal of Mathematics","volume":"96 1","pages":"261-287"},"PeriodicalIF":0.7000,"publicationDate":"2020-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"13","resultStr":"{\"title\":\"Mathematical Modelling of Listeriosis Epidemics in Animal and Human Population with Optimal Control.\",\"authors\":\"Shaibu Osman, O. Makinde, D. Theuri\",\"doi\":\"10.5556/j.tkjm.51.2020.2860\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Listeriosis is a serious disease caused by the germ Listeria monocytogenes. People usually become ill with listeriosis after eating contaminated food including meat. The disease primarily affects pregnant women, newborns, older adults, and people with weakened immune systems. In this paper, we propose and scrutinize a model problem describing the transmission dynamics of Listeriosis epidemic in animal and human population using the stability theory of differential equations. The model is qualitatively analysed for the basic reproduction number as well as possibility of forward and backward bifurcation with respect to the stability of disease free and endemic equilibria. The impact of the model parameters on the disease was evaluated via sensitivity analysis. An extension of the model to include time dependent control variables such as treatment, vaccination and education of susceptible (human) is carried out. Using Pontryagin’s Maximum Principle, we obtain the optimal control strategies needed for combating Listeriosis disease. Numerical simulation of the model is performed and pertinent results are displayed graphically and discussed quantitatively.\",\"PeriodicalId\":45776,\"journal\":{\"name\":\"Tamkang Journal of Mathematics\",\"volume\":\"96 1\",\"pages\":\"261-287\"},\"PeriodicalIF\":0.7000,\"publicationDate\":\"2020-11-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"13\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Tamkang Journal of Mathematics\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.5556/j.tkjm.51.2020.2860\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"MATHEMATICS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Tamkang Journal of Mathematics","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.5556/j.tkjm.51.2020.2860","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"MATHEMATICS","Score":null,"Total":0}
Mathematical Modelling of Listeriosis Epidemics in Animal and Human Population with Optimal Control.
Listeriosis is a serious disease caused by the germ Listeria monocytogenes. People usually become ill with listeriosis after eating contaminated food including meat. The disease primarily affects pregnant women, newborns, older adults, and people with weakened immune systems. In this paper, we propose and scrutinize a model problem describing the transmission dynamics of Listeriosis epidemic in animal and human population using the stability theory of differential equations. The model is qualitatively analysed for the basic reproduction number as well as possibility of forward and backward bifurcation with respect to the stability of disease free and endemic equilibria. The impact of the model parameters on the disease was evaluated via sensitivity analysis. An extension of the model to include time dependent control variables such as treatment, vaccination and education of susceptible (human) is carried out. Using Pontryagin’s Maximum Principle, we obtain the optimal control strategies needed for combating Listeriosis disease. Numerical simulation of the model is performed and pertinent results are displayed graphically and discussed quantitatively.
期刊介绍:
To promote research interactions between local and overseas researchers, the Department has been publishing an international mathematics journal, the Tamkang Journal of Mathematics. The journal started as a biannual journal in 1970 and is devoted to high-quality original research papers in pure and applied mathematics. In 1985 it has become a quarterly journal. The four issues are out for distribution at the end of March, June, September and December. The articles published in Tamkang Journal of Mathematics cover diverse mathematical disciplines. Submission of papers comes from all over the world. All articles are subjected to peer review from an international pool of referees.