褪黑素对人血液吞噬细胞杀菌活性的时序免疫调节作用

E. L. França, Alfredo Pereira Junior, S. L. Oliveira, A. Honório-França
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引用次数: 4

摘要

本文研究了褪黑素对血液吞噬细胞的时间免疫调节作用。用褪黑激素刺激细胞和用EPEC孵育的细胞表现出增强的超氧化物。在细菌存在的情况下,褪黑激素刺激单核(MN)和多形核(PMN)吞噬细胞表现出增强的超氧化物释放。褪黑素刺激MN吞噬细胞杀灭EPEC具有时间依赖性。在60和120分钟的孵育期间观察到最高的杀菌指数。褪黑素刺激PMN吞噬细胞,与时间无关,显示出增加的杀菌活性。褪黑素和吞噬细胞之间的相互作用支持松果体时间调节杀微生物过程的假设。
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Chronoimmunomodulation of melatonin on bactericidal activity of human blood phagocytes
In this work we studied the chronoimmunomodulation effect of melatonin on blood phagocytes. This cells stimulated with melatonin and incubated with EPEC presented enhanced superoxide. Mononuclear (MN) and polymorphonuclear (PMN) phagocytes stimulated with melatonin in the presence of bacteria showed enhanced superoxide release.EPEC killing by MN phagocytes stimulated with melatonin was time dependent. The highest bactericidal index were observed over the period of 60 and 120 minutes of incubation. PMN phagocytes stimulated with melatonin, independently of time, showed increased in the bactericidal activity. Interactions between melatonin and phagocytes support the hypothesis of pineal chronomodulation microbicidal processes.
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