生物3D打印耳廓重建的研究进展及展望

IF 6.8 3区 医学 Q1 ENGINEERING, BIOMEDICAL International Journal of Bioprinting Pub Date : 2023-08-07 DOI:10.36922/ijb.0898
Anna Onderková, Deepak M. Kalaskar
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引用次数: 0

摘要

先天性耳廓畸形或获得性耳廓创伤可导致耳廓重建的需要,并对一个人的生活质量产生负面影响。自体移植物、同种异体植入物和假体可用于治疗这些问题,但每一种都需要多个手术阶段,并且有局限性和并发症。三维(3D)生物打印技术有望创造出活的、针对患者的耳部替代品,从而降低手术的发病率。在这篇综述中,我们通过对27项研究的系统搜索和回顾来评估3D生物打印方法的现状,旨在在现有重建选择的背景下研究这一新兴技术。纳入的研究除一项临床试验外均为非随机实验研究。这些研究大多涉及体外和体内实验,证明了3D生物打印在为外科植入创造功能性和解剖学精确的工程软骨框架方面的潜力。从选择最合适的材料和细胞类型到解决支架变形和收缩问题,确定了各种优化打印的方法。3D打印有可能通过创造功能和美观的耳廓来彻底改变耳部重建手术。虽然对打印参数、生物墨水、细胞类型和材料的更多研究可以优化结果,但下一步是在人体中进行长期的体内临床试验。
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3D bioprinting for auricular reconstruction: A review and future perspectives
Congenital abnormalities or acquired trauma to the auricle can result in a need for ear reconstruction and negatively impact a person’s quality of life. Autografting, alloplastic implants, and prostheses are available to treat these issues, but each requires multiple surgical stages and has limitations and complications. Three-dimensional (3D) bioprinting promises to allow the creation of living, patient-specific ear substitutes that could reduce operative morbidity. In this review, we evaluate the current state of 3D bioprinting methods through a systematic search and review of 27 studies, aiming to examine this emerging technology within the context of existing reconstructive options. The included studies were all non-randomized experimental studies, except for a single pilot clinical trial. Most of these studies involved both in vitro and in vivo experiments demonstrating the potential of 3D bioprinting to create functional and anatomically accurate engineered cartilaginous frameworks for surgical implantation. Various ways of optimizing printing were identified, from choosing the most suitable material and cell type for the construct to addressing scaffold deformation and shrinkage issues. 3D printing has the potential to revolutionize reconstructive ear surgery by creating functional and aesthetically pleasing auricles. While more research into printing parameters, bioinks, cell types, and materials could optimize results, the next step is to conduct long-term in vivo clinical trials in humans.
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来源期刊
CiteScore
6.90
自引率
4.80%
发文量
81
期刊介绍: The International Journal of Bioprinting is a globally recognized publication that focuses on the advancements, scientific discoveries, and practical implementations of Bioprinting. Bioprinting, in simple terms, involves the utilization of 3D printing technology and materials that contain living cells or biological components to fabricate tissues or other biotechnological products. Our journal encompasses interdisciplinary research that spans across technology, science, and clinical applications within the expansive realm of Bioprinting.
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