Dapsone in the Treatment of Epidermolysis Bullosa Acquisita Long - Term Follow - Up

A 54 years old, chronic smoker, admitted to our department for itching bullous dermatosis lasting for 2 weeks. Clinical examination revealed clear strained vesicular bubbles based on an erythematous skin, grouped like rosette, clear and hemorrhagic bubble flaccid and tense., sitting at the neck, forearms, elbows, hands, knees, feet, navel hives plates at the forearm, trunk, periorbital erosions, erosions of the hard palate, erosive cheilitis (Figures 1,2,3,4). Nikolski was negatf. The histology and immunofluorecence confirmed diagnosis of EBA, and the patient was treated with colchicine and oral steroids, without improvement , then, was treated with methotrexate without any improvement. Then, we opted for dapsone, with good wound healing with a decline of 2 years. Discussion