{"title":"嗜碱性粒细胞活化抗原:分子机制和临床意义","authors":"P. Valent","doi":"10.2174/1874838401003010052","DOIUrl":null,"url":null,"abstract":"Basophil activation is a key finding in allergic reactions and also observed quite frequently in infectious dis- eases and autoimmune disorders. In allergic reactions, basophil-derived mediators such as histamine, contribute essen- tially to clinical symptoms. During IgE-dependent degranulation of basophils, a number of cell surface membrane and cy- toplasmic molecules become activated, show altered expression, or are translocated into the cell surface. Although little is known so far about the exact role of these activation-linked cell surface antigens, several of them are employed as diag- nostic parameters in allergic disorders. Other molecules are involved in the process of signalling and the consecutive re- lease of pro-allergic mediators, and have therefore been proposed as potential targets of therapy. The current article pro- vides a summary on activation-linked cell surface and cytoplasmic antigens in basophils, with special reference to poten- tial mechanisms underlying re-translocation or over-expression in activated cells, relevant signalling pathways, and clini- cal implications. This study was supported by: Fonds zur Forderung der Wissenschaftlichen Forschung in Osterreich, SFB grant # 018-20.","PeriodicalId":22835,"journal":{"name":"The Open Allergy Journal","volume":"124 1","pages":"52-59"},"PeriodicalIF":0.0000,"publicationDate":"2010-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"7","resultStr":"{\"title\":\"Basophil Activation Antigens: Molecular Mechanisms and Clinical Implications\",\"authors\":\"P. Valent\",\"doi\":\"10.2174/1874838401003010052\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Basophil activation is a key finding in allergic reactions and also observed quite frequently in infectious dis- eases and autoimmune disorders. In allergic reactions, basophil-derived mediators such as histamine, contribute essen- tially to clinical symptoms. During IgE-dependent degranulation of basophils, a number of cell surface membrane and cy- toplasmic molecules become activated, show altered expression, or are translocated into the cell surface. Although little is known so far about the exact role of these activation-linked cell surface antigens, several of them are employed as diag- nostic parameters in allergic disorders. Other molecules are involved in the process of signalling and the consecutive re- lease of pro-allergic mediators, and have therefore been proposed as potential targets of therapy. The current article pro- vides a summary on activation-linked cell surface and cytoplasmic antigens in basophils, with special reference to poten- tial mechanisms underlying re-translocation or over-expression in activated cells, relevant signalling pathways, and clini- cal implications. This study was supported by: Fonds zur Forderung der Wissenschaftlichen Forschung in Osterreich, SFB grant # 018-20.\",\"PeriodicalId\":22835,\"journal\":{\"name\":\"The Open Allergy Journal\",\"volume\":\"124 1\",\"pages\":\"52-59\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2010-11-26\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"7\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"The Open Allergy Journal\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.2174/1874838401003010052\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"The Open Allergy Journal","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.2174/1874838401003010052","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Basophil Activation Antigens: Molecular Mechanisms and Clinical Implications
Basophil activation is a key finding in allergic reactions and also observed quite frequently in infectious dis- eases and autoimmune disorders. In allergic reactions, basophil-derived mediators such as histamine, contribute essen- tially to clinical symptoms. During IgE-dependent degranulation of basophils, a number of cell surface membrane and cy- toplasmic molecules become activated, show altered expression, or are translocated into the cell surface. Although little is known so far about the exact role of these activation-linked cell surface antigens, several of them are employed as diag- nostic parameters in allergic disorders. Other molecules are involved in the process of signalling and the consecutive re- lease of pro-allergic mediators, and have therefore been proposed as potential targets of therapy. The current article pro- vides a summary on activation-linked cell surface and cytoplasmic antigens in basophils, with special reference to poten- tial mechanisms underlying re-translocation or over-expression in activated cells, relevant signalling pathways, and clini- cal implications. This study was supported by: Fonds zur Forderung der Wissenschaftlichen Forschung in Osterreich, SFB grant # 018-20.