利用气相色谱-质谱联用技术评价骆驼刺作为生物活性化合物的新来源

R. Mostafa, H. Essawy
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引用次数: 2

摘要

骆驼刺是豆科重要药用植物之一,俗称骆驼刺。本研究旨在利用气相色谱-质谱法鉴别毛蕊花地上部分的化学成分。采用三种极性不同的溶剂(水、甲醇和石油醚)进行化学成分的提取。GC-MS分析结果鉴定出多种化合物。从石油醚提取物中鉴定出39个化合物,甲醇提取物中鉴定出32个化合物,水提取物中鉴定出17个化合物。大多数已鉴定的化合物已被报道具有许多生物活性。其中,我们报道了10种新的抗癌化合物(维生素E;棕榈酸;Stigmast-5-en-3-ol;叶绿醇2-hexadecen-1-ol 3、7、11日15-tetramethyl;角鲨烯;棕榈酸;2-羟基-1-(羟甲基)乙酯;肟、methoxy-phenyl甲基N-hydroxyben-zenecarboximidoate;Ergost-5-en-3-ol;9,12-十八烯酸和法尼醇)采用三种溶剂提取,其中石油醚溶剂提取效果最佳。因此,我们认为毛蕊草具有开发成抗癌药物的巨大潜力。
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Assessment of camel thorn (Alhagi maurorum) as new sources of bioactive compounds using GC-MS technique
Alhagi maurorum (A. maurorum) is one of the medicinally important plants belonging to the family leguminasae, commonly known as camel thorn. This research was amid to identify the chemical compounds in the aerial part of A. maurorum using GC-mass analysis. Three solvents with different polarities were used for the extraction of chemical constituents (water, methanol and petroleum ether). The results of GC-MS analysis led to identification of various compounds. In total, thirty-nine compounds from petroleum ether extract, thirty-two compounds in methanolic extract and seventeen compounds in aqueous extract were identified. Majority of the identified compounds have been reported to possess many biological activities. Among them, we reported 10 new anticancer compounds (Vitamin E; Hexadecanoic acid; Stigmast-5-en-3-ol; Phytol,2-hexadecen-1-ol,3,7,11,15-tetramethyl; Squalene; Hexadecanoic acid; 2-hydroxy-1-(hydroxymethyl) ethyl ester; Oxime,methoxy-phenyl,methyl N-hydroxyben-zenecarboximidoate; Ergost-5-en-3-ol; 9,12- Octadecad-ienoic acid and Farnesol) from A. maurorum using three solvent, while the best effective solvent was petroluem ether. Therefore, we report that A. maurorum has great potential to be developed into anticancer drugs.
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