从生物活性植物中寻找新的抗真菌原理:隐藏的宝藏

Akm Shahidur Rahman, Nishat Parvin, Md. Moniruzzaman Khan, M. Razzaque
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摘要

如今,皮肤真菌感染在孟加拉国很常见,就像世界上其他国家一样。令人惊讶的是,这些感染已经变得非常难以治疗和永久治愈。我们知道,皮肤作为人体最大的器官,参与了人体的许多重要功能。它维持温度和盐水平衡,保护内部器官免受外部有害环境的侵害。它还参与人体许多重要成分的合成和排泄。烧伤、损伤或感染等各种有害刺激对皮肤的损害是皮肤病学关注的主要问题。目前,由于出现对现有抗真菌药物的耐药性,孟加拉国大多数卫生保健提供者都面临严重问题。大自然被认为是医药的宝藏。无数的天然化合物由于其可接受的功效,安全性和成本边际而在世界范围内使用。本综述旨在找出24种生物活性植物,这些植物在孟加拉国农村作为民间药物用于治疗包括真菌疾病在内的各种皮肤病。建议立即进行进一步的研究,以鉴定、分离和评估这些植物中存在的生物活性原理的抗真菌功效。成功筛选耐药真菌菌株及其与这些生物活性化合物的相互作用也将是一个有趣的研究时代。希望最有希望的化合物将被开发成新药并商业化生产,以对抗真菌流行日益增加的负担。KYAMC杂志第13卷,第02期,2022年7月:115-119
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A Review to Search Novel Antifungal Principles from Bioactive Plants: The Hidden Treasure
Now–a-days, fungal infections of the skin are very common in Bangladesh as like as the other countries in the world. Surprisingly, these infections have become very difficult to treat and cure permanently. We know that, skin takes part in many vital functions of the body as it is the largest organ. It maintains the temperature & salt-water balance and protects the internal organs from the external noxious environment. It is also involved in synthesis and excretion of many vital constituents of the body. Damage to the skin by various noxious stimuli like burns, injuries or infections are major concerns in Dermatology. At present, most of the health care providers in Bangladesh are facing serious problems due to the emergence of resistance to available anti-fungal drugs. The nature is considered as the hidden treasure of medicines. Innumerable natural compounds are used worldwide due to their acceptable margin of efficacy, safety & cost. The present review is involved to find out 24 (twenty four) bioactive plants used in rural Bangladesh as folklore medicines to treat various skin diseases including the fungal ones. Further researches are recommended immediately to identify, separate and assess the antifungal efficacy of bioactive principles present in these plants. Successful screening of the resistant fungal strains and their interaction with these bioactive compounds would also be an interesting era of study. Hopefully, the most promising compounds would be developed as newer medicines and manufactured commercially to combat the increasing burden of fungal epidemics. KYAMC Journal Vol. 13, No. 02, July 2022: 115-119
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