生物系统中金属离子的检测研究进展

IF 3.6 3区 化学 Q2 CHEMISTRY, ANALYTICAL Reviews in Analytical Chemistry Pub Date : 2020-01-01 DOI:10.1515/revac-2020-0118
Xiangqun Zheng, Wenyu Cheng, Chendong Ji, Jin Zhang, Meizhen Yin
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引用次数: 60

摘要

金属离子广泛存在于生物系统中,参与了物质运输、能量转化、信息传递和代谢调节等许多关键的生化过程,是人体不可缺少的物质。当缺乏或过量时,它们会引起健康问题。测量金属离子在单个细胞、组织和整个生物体中的含量和分布,对了解各种代谢过程和疾病诊断具有重要意义。在金属离子检测的各种方法中,有机染料荧光传感器因其具有荧光量子产率高、修饰方法简便、生物相容性好、操作简便、灵敏度高、检测速度快、检测实时性高等优点而备受关注。本文综述了生物系统中Na+、K+、Ca2+、Mg2+、Fe2+/Fe3+、Zn2+、Cu2+等金属离子的检测与成像的最新进展,并对该领域有待解决的问题提出了看法。
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Detection of metal ions in biological systems: A review
Abstract Metal ions are widely present in biological systems and participate in many critical biochemical processes such as material transportation, energy conversion, information transmission and metabolic regulation, making them indispensable substance in our body. They can cause health problems when deficiency or excess occurs. To understand various metabolic processes and facilitate diseases diagnosis, it is very important to measure the content and monitor the distribution of metal ions in individual cells, tissues and whole organisms. Among the various methods for metal ion detection, fluorescent sensors with organic dyes have attracted tremendous attention due to many advantages such as high fluorescence quantum yield, facile modification approaches and biocompatibility in addition to operation ease, high sensitivity, fast detection speed, and real-time detection. This review summarizes the recent progress on the detection and imaging of the metal ions in biological systems including Na+, K+, Ca2+, Mg2+, Fe2+/Fe3+, Zn2+, and Cu2+ provides an opinion on remaining challenges to be addressed in this field.
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来源期刊
Reviews in Analytical Chemistry
Reviews in Analytical Chemistry 化学-分析化学
CiteScore
7.50
自引率
0.00%
发文量
15
审稿时长
>12 weeks
期刊介绍: Reviews in Analytical Chemistry publishes authoritative reviews by leading experts in the dynamic field of chemical analysis. The subjects can encompass all branches of modern analytical chemistry such as spectroscopy, chromatography, mass spectrometry, electrochemistry and trace analysis and their applications to areas such as environmental control, pharmaceutical industry, automation and other relevant areas. Review articles bring the expert up to date in a concise manner and provide researchers an overview of new techniques and methods.
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