基于靶标和表型的药物筛选与策略研究进展

Shou-bao Wang, Zihan Wang, Lianhua Fang, Yang Lv, G. Du
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引用次数: 1

摘要

基于靶点和表型的药物筛选与策略研究进展王守宝1,*,王子涵1,方联华1,杨璐2,杜关华1,*1中国医学科学院-北京协和医学院药物研究所药物靶点鉴定与筛选北京市重点实验室,北京100050 2北京市多型药物重点实验室,北京100050中国医学科学院北京协和医学院,北京100050*通讯:shoubaowang@imm.ac.cn(王守宝);dugh@imm.ac.cn(杜冠华)。摘要:药物的发现和开发是一个复杂而昂贵的过程。有两种方法,表现型和基于靶标的方法,在寻求成功的上市许可时,每种方法在筛选新型候选药物方面都具有不同的优势。然而,候选药物的流失率继续增加。在这篇综述中,我们讨论了最近在表型筛选和基于靶标的药物发现筛选方面的成功和正在进行的进展。我们还探讨了战略和技术创新如何推动药物发现的新方法。药物发现有两种方法。
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Advances of the Target-Based and Phenotypic Screenings and Strategies in Drug Discovery
Review Advances of the Target-Based and Phenotypic Screenings and Strategies in Drug Discovery Shoubao Wang 1,*, Zihan Wang1, Lianhua Fang1, Yang Lv2, and Guanhua Du1,* 1 Beijing Key Laboratory of Drug Targets Identification and Drug Screening, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100050, China. 2 Beijing Key Laboratory of Polymorphic Drugs, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100050, China. * Correspondence: shoubaowang@imm.ac.cn (Shoubao Wang); dugh@imm.ac.cn (Guanhua Du).     Received: 8 November 2022 Accepted: 15 November 2022 Published: 21 December 2022   Abstract: Drug discovery and development is a complex and expensive process. There are two approaches, phenotypic and target-based approaches, each holding different advantages for screening novel drug candidates when pursuing successful marketing authorization. However, the attrition rates of drug candidates continue to increase. In this review, we discuss recent successes and ongoing advances in phenotypic screening and target-based screening for drug discovery. We also explore how strategic and technological innovations may fuel new approaches in drug discovery. There are two approaches in drug discovery.
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