{"title":"偏头痛和爱丽丝梦游仙境综合症双重先兆的神经生理学:有联系吗?","authors":"Chirchiglia Domenico, Serena Lavano, Pasquale Chirchiglia","doi":"10.1016/j.npbr.2019.02.001","DOIUrl":null,"url":null,"abstract":"<div><h3>Objectives</h3><p>Alice in Wonderland syndrome (AIWS) is a pathological condition characterized by distortions of visual representation, with symptoms deforming images, figures, bodies, objects, which are seen larger or smaller than normal. Causes are sought in infectious diseases, psychiatric illness, migraines. It may be associated with alterations in the body schema such as non-recognition of own body in space. It's a rare form of visual aura. Unlike it, migraine with aura is a very frequent disorder, in which the phenomenon of visual aura is considered a consequence of cortical spreading depression(CSD), a wave of depolarization that propagates from the occipital cortex, creating a vasoconstriction and visual disturbances.</p></div><div><h3>Methods</h3><p>Recent studies have found an anatomical correlation between visual and somatosensory disorders such as those found in AIWS, located in the temporo- parieto-occipital junction.Neuroimaging studies allowed to identify the CSD and the occipital cortex responsible for the mechanism of the visual aura and the involvement of the parietal cortex in the genesis of the somatosensory aura.</p></div><div><h3>Results</h3><p>The mechanism of the initiation of the stage of visual and somatosensory aura could be a combination of two events.</p></div><div><h3>Conclusions</h3><p>Literature data now offer agreed confirmations on the role of the CSD associated to somatosensory aura.</p></div>","PeriodicalId":49756,"journal":{"name":"Neurology Psychiatry and Brain Research","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2019-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.npbr.2019.02.001","citationCount":"1","resultStr":"{\"title\":\"Neurophysiology of a double aura in migraine and Alice in wonderland syndrome: Is there a link?\",\"authors\":\"Chirchiglia Domenico, Serena Lavano, Pasquale Chirchiglia\",\"doi\":\"10.1016/j.npbr.2019.02.001\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Objectives</h3><p>Alice in Wonderland syndrome (AIWS) is a pathological condition characterized by distortions of visual representation, with symptoms deforming images, figures, bodies, objects, which are seen larger or smaller than normal. Causes are sought in infectious diseases, psychiatric illness, migraines. It may be associated with alterations in the body schema such as non-recognition of own body in space. It's a rare form of visual aura. Unlike it, migraine with aura is a very frequent disorder, in which the phenomenon of visual aura is considered a consequence of cortical spreading depression(CSD), a wave of depolarization that propagates from the occipital cortex, creating a vasoconstriction and visual disturbances.</p></div><div><h3>Methods</h3><p>Recent studies have found an anatomical correlation between visual and somatosensory disorders such as those found in AIWS, located in the temporo- parieto-occipital junction.Neuroimaging studies allowed to identify the CSD and the occipital cortex responsible for the mechanism of the visual aura and the involvement of the parietal cortex in the genesis of the somatosensory aura.</p></div><div><h3>Results</h3><p>The mechanism of the initiation of the stage of visual and somatosensory aura could be a combination of two events.</p></div><div><h3>Conclusions</h3><p>Literature data now offer agreed confirmations on the role of the CSD associated to somatosensory aura.</p></div>\",\"PeriodicalId\":49756,\"journal\":{\"name\":\"Neurology Psychiatry and Brain Research\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2019-06-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/j.npbr.2019.02.001\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Neurology Psychiatry and Brain Research\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0941950018303087\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"Medicine\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Neurology Psychiatry and Brain Research","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0941950018303087","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"Medicine","Score":null,"Total":0}
Neurophysiology of a double aura in migraine and Alice in wonderland syndrome: Is there a link?
Objectives
Alice in Wonderland syndrome (AIWS) is a pathological condition characterized by distortions of visual representation, with symptoms deforming images, figures, bodies, objects, which are seen larger or smaller than normal. Causes are sought in infectious diseases, psychiatric illness, migraines. It may be associated with alterations in the body schema such as non-recognition of own body in space. It's a rare form of visual aura. Unlike it, migraine with aura is a very frequent disorder, in which the phenomenon of visual aura is considered a consequence of cortical spreading depression(CSD), a wave of depolarization that propagates from the occipital cortex, creating a vasoconstriction and visual disturbances.
Methods
Recent studies have found an anatomical correlation between visual and somatosensory disorders such as those found in AIWS, located in the temporo- parieto-occipital junction.Neuroimaging studies allowed to identify the CSD and the occipital cortex responsible for the mechanism of the visual aura and the involvement of the parietal cortex in the genesis of the somatosensory aura.
Results
The mechanism of the initiation of the stage of visual and somatosensory aura could be a combination of two events.
Conclusions
Literature data now offer agreed confirmations on the role of the CSD associated to somatosensory aura.
期刊介绍：
Neurology, Psychiatry & Brain Research publishes original papers and reviews in
biological psychiatry,
brain research,
neurology,
neuropsychiatry,
neuropsychoimmunology,
psychopathology,
psychotherapy.
The journal has a focus on international and interdisciplinary basic research with clinical relevance. Translational research is particularly appreciated. Authors are allowed to submit their manuscript in their native language as supplemental data to the English version.
Neurology, Psychiatry & Brain Research is related to the oldest German speaking journal in this field, the Centralblatt fur Nervenheilkunde, Psychiatrie und gerichtliche Psychopathologie, founded in 1878. The tradition and idea of previous famous editors (Alois Alzheimer and Kurt Schneider among others) was continued in modernized form with Neurology, Psychiatry & Brain Research. Centralblatt was a journal of broad scope and relevance, now Neurology, Psychiatry & Brain Research represents a journal with translational and interdisciplinary perspective, focusing on clinically oriented research in psychiatry, neurology and neighboring fields of neurosciences and psychology/psychotherapy with a preference for biologically oriented research including basic research. Preference is given for papers from newly emerging fields, like clinical psychoimmunology/neuroimmunology, and ideas.
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