一种新的UDP-GlcNAc类似物对酿酒酵母几丁质合成酶的抑制作用

Journal of enzyme inhibition Pub Date : 2001-01-01 DOI:10.1080/14756360109162360

J. Behr, Isabelle Gautier-Lefebvre, Claude Mvondo-Evina, G. Guillerm, N. Ryder

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引用次数: 9

摘要

本文描述了一种新的UDP-G1cNAc竞争者(I)的合成和生物学评价，该竞争者旨在模拟几丁质合成酶催化的酶促反应中糖供体的过渡状态。化合物(1)与UDP-G1cNAc相比，对酿酒酵母的几丁质合成酶具有竞争性抑制作用，但抗真菌活性很小。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Inhibition of Chitin Synthetase from Saccharomyces cerevisiae by a New UDP-GlcNAc Analogue

The synthesis and biological evaluation of a new UDP-G1cNAc competitor (I), designed to mimic the transition state of the sugar donor in the enzymatic reaction catalysed by chitin synthetase, is described. Compound (I) was found to competitively inhibit chitin synthetase from Saccharomyces cerevisiae with respect to UDP-G1cNAc, but displayed minimal antifungal activity.

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Journal of enzyme inhibition

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