淀粉样肽在二氧基二硫化物功能化纳米金胶体粒子上的自组装

K. Yokoyama, Amy Tran, R. Priefer
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引用次数: 1

摘要

为了更稳定地产生低聚物形式的β淀粉样蛋白(即纤维形成的关键中间体,最终导致阿尔茨海默病),用硝基、苯基、氯基和甲氧基二硫化物对金胶体表面进行了功能化,并在二甲基亚砜环境中研究了分子相互作用。在pH值为pHo时,随着外部pH值的降低,观察到颜色变化的转变。作为二硫化物被吸附在胶体表面的证据,pHo值依赖于二苯氧基二硫化物化合物的每个取代基。pHo的变化趋势与f值(Swain-Lupton Field constant)呈抛物线关系。在pH值为4 ~ 10之间,甲氧基二苯氧基二硫化物对金胶体表面的功能化在重复峰移中获得了较大的振幅,表明在可逆过程下形成了低聚物
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Self-Assembly of Amyloid Beta Peptide Over Dialkoxy Disulfide Functionalized Nano Gold Colloidal Particles
Aiming to more stably produce an oligomer form of amyloid beta (i.e., a key intermediate of fibrillogenesis which eventually leads to Alzheimer’s disease), the surface of gold colloids were functionalized with nitro-, phenyl-, chloro-, and methoxy-dibenzyloxy disulfide, and molecular interactions were investigated in a dimethyl sulfoxide environment. The transition of color change was observed at pHo as the pH value was lowered externally. As evidence of disulfide being adsorbed on the colloidal surface, the pHo values were dependent of each substituent of the dibenzyloxy disulfide compounds. The trend of pHo exhibited a parabolic relationship as a function of F-value (Swain-Lupton Field constant). Functionalization of gold colloidal surface with methoxy-dibenzyloxy disulfide achieved larger amplitude in repetitive peak shift between pH 4 and 10 implying a formation of an oligomer under the reversible process
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