{"title":"肿瘤干细胞维持和调节中的发育信号","authors":"Sweta Dash, R. Sunkara, S. Waghmare","doi":"10.4103/2349-3666.240619","DOIUrl":null,"url":null,"abstract":"Tissue stem cells self-renew throughout the life of an organism thereby maintaining tissue homeostasis and prevent cancer. The major signalling pathways such as Wnt, Notch and Sonic hedgehog control the stem cell regulation and their deregulation leads to cancer. Recent evidences showed that there exists a subset of cells within tumour termed as cancer stem cells (CSCs). These CSCs escape the conventional chemo-radiotherapy and further lead to tumour relapse followed by metastasis. This review focuses on the developmental signalling pathways that are involved in the regulation and maintenance of normal stem cells and CSCs. Understanding the molecular mechanism may be useful to specifically target the CSCs while sparing the normal stem cells to reduce tumorigenecity.","PeriodicalId":34293,"journal":{"name":"Biomedical Research Journal","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":"{\"title\":\"Developmental signalling in maintenance and regulation of cancer stem cells\",\"authors\":\"Sweta Dash, R. Sunkara, S. Waghmare\",\"doi\":\"10.4103/2349-3666.240619\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Tissue stem cells self-renew throughout the life of an organism thereby maintaining tissue homeostasis and prevent cancer. The major signalling pathways such as Wnt, Notch and Sonic hedgehog control the stem cell regulation and their deregulation leads to cancer. Recent evidences showed that there exists a subset of cells within tumour termed as cancer stem cells (CSCs). These CSCs escape the conventional chemo-radiotherapy and further lead to tumour relapse followed by metastasis. This review focuses on the developmental signalling pathways that are involved in the regulation and maintenance of normal stem cells and CSCs. Understanding the molecular mechanism may be useful to specifically target the CSCs while sparing the normal stem cells to reduce tumorigenecity.\",\"PeriodicalId\":34293,\"journal\":{\"name\":\"Biomedical Research Journal\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2015-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Biomedical Research Journal\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.4103/2349-3666.240619\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biomedical Research Journal","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4103/2349-3666.240619","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Developmental signalling in maintenance and regulation of cancer stem cells
Tissue stem cells self-renew throughout the life of an organism thereby maintaining tissue homeostasis and prevent cancer. The major signalling pathways such as Wnt, Notch and Sonic hedgehog control the stem cell regulation and their deregulation leads to cancer. Recent evidences showed that there exists a subset of cells within tumour termed as cancer stem cells (CSCs). These CSCs escape the conventional chemo-radiotherapy and further lead to tumour relapse followed by metastasis. This review focuses on the developmental signalling pathways that are involved in the regulation and maintenance of normal stem cells and CSCs. Understanding the molecular mechanism may be useful to specifically target the CSCs while sparing the normal stem cells to reduce tumorigenecity.