COVID-19患者肺部受累严重程度作为肾功能障碍和凝血功能障碍的预测因子

Farinaz Fattahi, M. Farnia, Bareza Rezaei, Hooman Rafiei, Aisan Ghasemi Oskui, A. Amiri, Mohammad Reza Rezaei
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摘要

导言:肾功能障碍、凝血功能障碍和肺部受累是COVID-19病毒引起的最常见疾病。目的:本研究旨在探讨COVID-19患者肺部受累程度与肾功能障碍和凝血功能障碍的相关性。患者和方法:本描述性分析研究对2020年12月至2021年6月在克尔曼沙阿伊玛目礼萨医院转诊的97例COVID-19患者进行了研究。收集肺受累程度、肾功能检查和凝血实验室数据。采用Logistic回归检验探讨肺累及肾功能不全和凝血功能障碍的相关性。结果:97例患者中,男性53例(54.6%),平均年龄59.31±16.44岁。肺受累程度与肾功能检查(包括血尿素氮、血清肌酐)和凝血因子(包括凝血酶原时间(PT)、部分凝血活酶时间(PTT)、d -二聚体)的相关性均有统计学意义(P > 0.05)。肺受累严重程度可显著预测肾功能障碍和凝血功能障碍。结论:肺部受累严重程度可预测COVID-19患者肾功能障碍和凝血功能障碍。
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COVID-19 patients’ lung involvement severity as a predictor of kidney dysfunction and coagulopathy disorders
Introduction: Kidney dysfunction, coagulopathy disorders, and lung involvement are the most common disorders caused by the COVID-19 virus. Objectives: This study aimed to investigate the correlation of lung involvement severity with kidney dysfunction and coagulopathy disorders in COVID-19 patients. Patients and Methods: This descriptive-analytical study was conducted on 97 patients with COVID-19 referred to Imam Reza hospital in Kermanshah from December 2020 to June 2021. Lung involvement severity, kidney function tests, and coagulation laboratory data were collected. Logistic regression test was conducted to explore the correlation between lung involvement with kidney dysfunction and coagulopathy disorders. Results: Out of 97 patients, 53 (54.6%) were male, with a mean age of 59.31 ± 16.44 years. The correlation between lung involvement severity with kidney function tests, including, blood urea nitrogen, serum creatinine, and coagulation factors, including prothrombin time (PT), partial thromboplastin time (PTT), and D-dimer, were significant (P > 0.05). Lung involvement severity significantly predicted kidney dysfunction and coagulopathy disorders. Conclusion: Lung involvement severity would be able to predict kidney dysfunction and coagulopathy disorders in patients with COVID-19.
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