用纳米沉淀法制备高稳定超声辅助姜黄素纳米晶体

C. Moorthi, K. Kathiresan
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引用次数: 45

摘要

目的利用纳米沉淀法制备高稳定性超声辅助姜黄素纳米晶体,克服姜黄素水溶性差的缺点。方法采用纳米沉淀法制备十二烷基硫酸钠包被姜黄素纳米晶体和poloxamer 188包被姜黄素纳米晶体,并对其粒径和相关参数进行表征。结果与纯姜黄素相比,spoloxam188涂层在分布宽度(d90中约250倍)和平均粒径(平均体积重量约260倍)上显著减小。同样,与纯姜黄素相比,十二烷基硫酸钠涂层在分布宽度(d90中约为1000倍)和平均粒径(平均体积重量约为750倍)上产生了显着的尺寸减小。十二烷基硫酸钠包被的姜黄素纳米晶体即使在一周后也比波洛沙姆包被的姜黄素纳米晶体分布窄。结论月桂醇硫酸钠的阴离子性质使其具有较高的zeta电位和较大的静电力,克服了范德华引力和万有引力的作用,阻止了纳米晶体的聚集,形成了窄尺寸、高稳定性的姜黄素纳米晶体。
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Fabrication of highly stable sonication assisted curcumin nanocrystals by nanoprecipitation method

Objectives

The present study was aimed to fabricate highly stable sonication assisted curcumin nanocrystals by nanoprecipitation method to overcome the poor aqueous solubility of curcumin.

Methods

Sodium lauryl sulfate coated curcumin nanocrystals and poloxamer 188 coated curcumin nanocrystals were prepared using nanoprecipitation method and characterized for particle size and related parameters.

Results

Poloxamer 188 coating has produced a significant size reduction in the distribution width (approximately 250 times in D 90) and in the average particle size (approximately 260 times in volume weight mean) with respect to pure curcumin. Similarly, sodium lauryl sulfate coating has produced a significant size reduction in the distribution width (approximately 1000 times in D 90) and in the average particle size (approximately 750 times in volume weight mean) with respect to pure curcumin. Sodium lauryl sulfate coated curcumin nanocrystals has shown a narrow distribution even after one week than the poloxamer coated curcumin nanocrystals.

Conclusions

The study concludes that the anionic nature of sodium lauryl sulfate has provided higher zeta potential and offered high electrostatic force which overcomes the van der Waals force of attraction and gravitational force leading to prevention of nanocrystal aggregation resulting in narrow sized high stable curcumin nanocrystals.

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