The Drosophila NMJ: a genetic model system for synapse formation and function

Drosophila is the most genetically malleable animal whichpermits detailed electrophysiological studies. As such, it is an invaluable tool for the genetic dissection of nervous system development and function. In particular, the neuromuscular junction (NMJ) is a large, accessible synapse which can be analysed at all stages of its development. We have been using this synapse to characterize mutations in genes essential to synaptic development and function. These studies suggest that Drosophila synapses develop and function similarly to the synapses of higher animals, using conserved genetic and molecular mechanisms. In the long term, this system will allow us to mutate the genome systematically to identify and describe the genetic and molecular pathways directing the construction of a synapse.