项目简介:拉丁美洲年轻女性乳腺癌多中心研究(PRECAMA 研究)。

IF 8.6 1区 物理与天体物理 Q1 ASTRONOMY & ASTROPHYSICS Astrophysical Journal Supplement Series Pub Date : 2019-09-01 DOI:10.21149/10466
Isabelle Romieu, Carine Biessy, Gabriela Torres-Mejía, Angélica Ángeles-Llerenas, Gloria Inés Sánchez, Mauricio Borrero, Carlos Andrés Ossa, Carolina Porras, Ana Cecilia Rodríguez, Rebecca Ocampo, María Luisa Garmendia, Eva Bustamante, Magali Olivier, Peggy Porter, Sabina Rinaldi
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引用次数: 0

摘要

目的描述研究拉丁美洲年轻女性乳腺癌病因的多中心项目的原理和方法:国际癌症研究机构(International Agency for Research on Cancer)在拉丁美洲的四个国家开展了一项基于人群的病例对照国际合作研究:智利、哥伦比亚、哥斯达黎加和墨西哥(PRECAMA 研究)。该研究制定了标准化方法,以收集有关生殖变量、生活方式、人体测量、饮食、临床和病理数据以及生物标本的信息。这项研究将扩展到该地区的其他国家:PRECAMA 的独特之处在于其多学科方法,将遗传学、基因组学、代谢组学与生活方式因素相结合。通过该项目获得的数据将有助于确定年轻女性乳腺癌分子亚型的主要风险因素,这对拉丁美洲的预防和有针对性的筛查计划非常重要。
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Project profile: a multicenter study on breast cancer in young women in Latin America (PRECAMA study).

Objective: To describe the rationale and the methodology of a multicenter project to study the etiology of breast cancer in young Latin American women.

Materials and methods: The International Agency for Research on Cancer has established an international collaborative population-based case-control study in four countries in Latin America: Chile, Colombia, Costa Rica, and Mexico (the PRECAMA study). Standardized methodologies were developed to collect information on reproductive variables, lifestyle, anthropometry, diet, clinical and pathological data, and biological specimens. The study will be extended to other countries in the region.

Conclusions: PRECAMA is unique in its multidisciplinary approach that combines genetics, genomics, and metabolomics with lifestyle factors. Then data generated through this project will be instrumental to identify major risk factors for molecular subtypes of breast cancer in young women, which will be important for pre- vention and targeted screening programs in Latin America.

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来源期刊
Astrophysical Journal Supplement Series
Astrophysical Journal Supplement Series 地学天文-天文与天体物理
CiteScore
14.50
自引率
5.70%
发文量
264
审稿时长
2 months
期刊介绍: The Astrophysical Journal Supplement (ApJS) serves as an open-access journal that publishes significant articles featuring extensive data or calculations in the field of astrophysics. It also facilitates Special Issues, presenting thematically related papers simultaneously in a single volume.
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