Interference Model for NMDA Receptor

Synapse is the point of impulse conduction between neurons. After receiving action potential at the axonal terminal, the presynaptic neuron releases neurotransmitter chemicals to the postsynaptic neuron. The agonist molecules bind to the receptors of the postsynaptic neuron and change its functions. The proposed work is centered on interference in two synaptic system due to mobility of NMDA neurotransmitter with probability of leaking to the nearby synapse. Such leaky event of neurotransmitters from one synapse to nearby synapses could contribute either positively or negatively, depending on the type of ion channels it opens. The proposed model suggests change in amplitude and strength of the post-synaptic received signal significantly depends upon this leaky parameter. The model suggests increase in leakage of NMDA neurotransmitter results in lowered depolarization of post-synaptic potential and increased depolarization in nearby post-synapse and vice versa.