加拿大孕妇妊娠早期体重指数和体重变化与持久性有机污染物浓度的关系

Challenges Pub Date : 2023-02-16 DOI:10.3390/challe14010013
Marianne Lévesque, Mariame O. Ouédraogo, Romina Fakhraei, Alysha Dingwall Harvey, Elizabeth Bratton, Mark Walker, L. Dodds, L. Gaudet
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摘要

持久性有机污染物(POPs)是对妊娠和新生儿结局具有明显影响的有毒化学品。在加拿大的背景下,妊娠早期体重指数(BMI)和产前体重变化与循环POP浓度的关系尚不清楚。本研究旨在探讨加拿大孕妇妊娠早期体重指数、孕前至妊娠6-13周体重变化与妊娠早期血浆POP浓度之间的关系。我们分析了作为环境化学品母婴研究(MIREC)研究的一部分收集的数据,并根据妊娠早期BMI和妊娠早期体重变化类别评估POP浓度。我们使用Kruskal-Wallis测试来测试总体差异。使用删减回归模型评估孕早期母亲BMI、体重变化和41种持久性有机污染物血浆浓度之间的关系。在控制了潜在的混杂因素后,不同BMI类别的妊娠早期血浆中多种持久性有机污染物的浓度存在显著差异,体重不足/体重正常个体的浓度最高,III类肥胖个体的浓度最低。我们的研究结果提供了肥胖个体较高循环POP水平的初步证据,并与先前关于妊娠期循环POP浓度与BMI呈负相关的研究结果一致。未来的研究应前瞻性地评估孕期体重变化与POP浓度之间的相互作用,从而为肥胖孕妇提供孕期增重建议。
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Relationships of First-Trimester Body Mass Index and Weight Change with Persistent Organic Pollutant Concentrations in Pregnant Canadian Individuals
Persistent organic pollutants (POPs) are toxic chemicals with demonstrable effects on pregnancy and neonatal outcomes. The associations of early pregnancy body mass index (BMI) and antenatal weight changes with circulating POP concentrations are poorly understood in the Canadian context. The aim of this study was to explore the relationship between maternal BMI in the first trimester, weight change from pre-pregnancy to 6–13 weeks of pregnancy, and first-trimester plasma POP concentrations among Canadian pregnant women. We analyzed data collected as part of the Maternal-Infant Research on Environmental Chemicals (MIREC) study and evaluated POP concentrations based on first-trimester BMI and early gestational weight change categories. We tested for overall differences using Kruskal-Wallis tests. The associations between first-trimester maternal BMI, weight change, and plasma concentrations of 41 POPs were evaluated using censored regression models. After controlling for potential confounders, first-trimester plasma levels of multiple POPs differed significantly across BMI categories, with the highest concentrations in underweight/normal-weight individuals and the lowest in class III obese individuals. Our findings provide preliminary evidence of higher circulating POP levels in individuals with obesity and align with previous findings of an inverse relationship between circulating POP concentrations and BMI in pregnancy. Future studies should prospectively evaluate the interplay between weight change and POP concentrations throughout pregnancy to inform gestational weight gain recommendations for pregnant individuals with obesity.
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