利用辅酶Q10调节撒哈拉以南非洲地区的肥胖

Doris Nnenna Ajibo, Ifeoma Cynthia Ekenna
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引用次数: 0

摘要

肥胖是一种代谢性疾病,由体内大量脂肪堆积和能量消耗不足引起。它与较短的预期寿命有关,与各种癌症类型有关,并与糖尿病、动脉粥样硬化和高血压等继发性代谢疾病有关。由于白色脂肪组织沉积的增加,氧化应激可导致肥胖,而肥胖可导致体内氧化应激增加。辅酶Q10(泛醌)是一种内源性抗氧化剂,具有抗氧化特性,有助于减少氧化应激。增强超氧化物歧化酶和谷胱甘肽过氧化物酶的抗氧化活性,减少脂质过氧化,中和自由基,促进体内维生素E和C的再生。它以泛醇或泛醌的形式存在。辅酶q10可以在饮食和补充剂中找到。它可以制成糖浆、片剂、软凝胶胶囊、硬壳胶囊或口服粉末作为补充。它是一种溶解度低但渗透性好的生物制药类化合物。当辅酶q10补充剂与脂肪膳食一起服用时,其生物利用度会增加。辅酶q10减缓肥胖相关动脉粥样硬化的演变,并有助于减轻肥胖造成的有害身体环境。
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Modulation of Obesity in Sub-Saharan Africa Using Coenzyme Q10
Obesity is a metabolic disease caused by a large buildup of fat in the body and a deficit in energy consumption compared to energy disposal. It has been related to a shorter life expectancy, has been connected to various cancer types, and has been linked to secondary metabolic illnesses such as diabetes, atherosclerosis, and hypertension. Due to an increase in white adipose tissue deposition, oxidative stress can lead to obesity, and obesity can lead to increased oxidative stress in the body. Coenzyme Q10 (Ubiquinone) is an endogenous anti-oxidant with anti-oxidant properties that aids to reduce oxidative stress. It boosts the anti-oxidant activity of superoxide dismutase and glutathione peroxidase, reduces lipid peroxidation, neutralises free radicals, and promotes vitamin E and C regeneration in the body. It can be found in the form of ubiquinol or ubiquinone. CoQ10 may be found in both diet and supplements. It can be made as a syrup, tablet, soft gel capsule, hard shell capsule, or oral powder as a supplement. It is classified as a biopharmaceutical class II compound with low solubility but good permeability. When CoQ10 supplement is taken with a fatty meal, its bioavailability is increased. CoQ10 slows the evolution of obesity-related atherosclerosis and helps to mitigate the harmful bodily environment caused by obesity.
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