Development of an Endocrine Profiles Based Mathematical Model for the Estrous Cycle in Indian Crossbred CowsDevelopment of an Endocrine Profiles Based Mathematical Model for the Estrous Cycle in Indian Crossbred Cows

Declined fertility of the high-yielding dairy cows reared under intensive condition of management is of great concern not only for India but for the whole world. The bovine estrous cycle, particularly the estrus, is tightly controlled by the complex interplay of various organs and hormones. Mathematical modeling of the bovine estrous cycle could help in understanding the dynamics of this complex biological system. The authors, therefore, developed a mechanistic mathematical model for the estrous cycle of Indian crossbred cows that exclusively includes the key hormones that interact to control these processes. The authors used the data generated by them for approximately 163 estrous cycles having 1793 readings related to different hormones like LH, FSH, progesterone, estrogen, etc., under the control of the hypothalamo-pituitary-gonadal (ovarian) axis. The developed model was capable enough to generate successive estrous cycles of 21-day length. The model contains seven differential equations and 34 parameters. By simulating the developed model, a set of equations and parameters that were obtained were found to describe vividly the system consistent with empirical knowledge. In conclusion, the authors for the first time developed a mechanistic mathematical model of the estrous cycle for the Indian crossbred cows and it can be used for predicting hormonal inter milieu of the complex biological system without spending much time and money towards laboratory estimation. The developed model may also be used as a basis for more elaborate models that can predict the effects of external manipulations and genetic differences in Indian bovines. Keywords: Indian crossbred cow, hormones, differential equations, systems biology Cite this Article Mondal M, Karunakaran M, Ghosh MK et al. Development of an Endocrine Profiles Based Mathematical Model for The Estrous Cycle in Indian Crossbred Cows. Research & Reviews: Journal of Veterinary Science and Technology . 2015; 4(3): 35–38p.