香合欢水/酒精提取物对雄性小鼠精子质量、性激素和生殖组织的毒性影响

F. Dehghani, Aseyeh Heshmatpour, M. Panjehshahin, T. Talaei-Khozani
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引用次数: 16

摘要

香薷被认为是一种壮阳剂;然而,它可能会引起一些副作用。本研究旨在探讨合欢提取物对男性生殖系统的影响。将40只雄性小鼠分为5组:阴性对照组灌胃,阳性对照组灌胃,3个实验组灌胃250、500、1000 mg/kg/d的水/醇提物,连续34 d。对精子数量和活力以及性激素水平进行了评估。对生殖组织进行组织学制备,光镜下观察。结果表明,与对照组相比,高剂量治疗的动物精子数量、活力和睾丸激素显著下降,但雌二醇浓度显著增加。提取物处理过的动物的精管中含有的精子比对照组动物少。似乎尽管芳香合欢提取物有壮阳作用,但它减少了精子的发生。关键词:生殖,合子,精子
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Toxic effects of water/alcoholic extract of Syzygium aromaticum on sperm quality, sex hormones and reproductive tissues in male mouse
Syzygium aromaticum was considered as an aphrodisiac agent; however, it may cause some side effects. The aim of this study was to examine the effects of Syzygium aromaticum extract on male reproductive system. To do this, forty male mice were divided into 5 groups: negative control was fed with vehicle, positive control was fed with aphridite and three experimental groups were fed with 250, 500 and 1000 mg/kg/day of water/alcohol extract of S. aromaticum for 34 days. The sperm count and motility and also the sex hormones level were assessed. The reproductive tissues were prepared histologically and studied under the light microscope. The results indicated the high dose-treated animals showed a significant decline in sperm count, motility and testosterone but a significant increase in estradiol concentration compared with the control group. The seminiferous tubules of extract-treated animals contained fewer sperms than in those of control animals. It seems that in spite of aphrodiastic activity of the Syzygium aromaticum extract, it reduced spermatogenesis. Keywords: Reproduction, Syzygium aromaticum, Sperm
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