黏附给药系统研究进展

P. Pandey, M. Saini, Neeta
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引用次数: 13

摘要

任何剂型的主要目标都是将最佳治疗量的活性剂输送到体内适当的部位,以达到和维持所需的药物浓度。黏附给药系统是一种有效的给药系统,与其他口服控释剂型相比,在特定部位给药,延长药物在靶部位的滞留时间方面具有各种优点。这些系统的主要优点包括避免药物的第一次代谢,从而在靶部位获得高浓度的药物。口腔黏附系统具有控制和延长释放的潜力,从而获得更好的性能和患者依从性。本文简要综述了黏附给药系统的优点、黏附机制、影响黏附给药系统的不同因素。
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MUCOADHESIVE DRUG DELIVERY SYSTEM: A REVIEW
The major objective of any dosage form is to deliver an optimum therapeutic amount of active agent to the proper site in the body to attain constant & maintenance of the desired drug concentration. Mucoadhesive drug delivery systems are effective delivery systems with various advantages as compared to other oral controlled release dosage forms in terms of drug delivery at specific sites with prolonged retention time of drugs at target sites. The main advantage of these systems includes avoiding first pass metabolism of the drugs and hence availability of high drug concentration at target site. Oral mucoadhesive systems have potential ability for controlled and extended release profile so as to get better performance and patient compliance. The present manuscript briefly reviews the benefits of mucoadhesive drug delivery systems, mechanisms involved in mucoadhesion, different factors affecting mucoadhesive drug delivery systems.
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