以E-NOSE为基础的呼吸测试分析,以解决COVID-19大流行期间因空气污染造成的慢性肺水病的早期检测

Ayers Gilberth Ivano Kalaij
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摘要

背景:尽管有6400万人患有慢性阻塞性肺病,但研究表明,由于多种原因,全世界70%的慢性阻塞性肺病患者未得到充分诊断。充分和快速的检测对于确定该病的预后至关重要。然而,许多肺功能测试仍然存在缺点和局限性。Covid-19大流行时代限制了我们的流动性,增加了家庭空气污染暴露的风险,从而增加了患慢性阻塞性肺病的风险。因此,需要替代方案来尽快检测和筛查与家庭空气污染有关的COPD患者。讨论:电子鼻技术已被证明能有效侦测各种呼吸道疾病。这可能是提供COPD诊断测试的替代解决方案,通常使用肺活量测定法,其缺点是。基于呼吸指纹的挥发性有机化合物检测可能是呼吸系统疾病,甚至是慢性阻塞性肺病的传感器生物标志物。如果在Covid-19大流行时期将其与印度尼西亚的初级保健系统相结合,它可能成为早期发现COPD的解决方案。结论:结合电子鼻呼吸指纹检测具有无创、患者满意的优点,有望成为早期、准确诊断慢性阻塞性肺病的解决方案。
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INTEGRASI ANALISIS UJI CETAK NAPAS BERBASIS E-NOSE SEBAGAI SOLUSI BARU DETEKSI DINI PENYAKIT PARU OBSTRUKTIF KRONIK AKIBAT POLUSI UDARA DI LINGKUNGAN RUMAH PADA MASA PANDEMI COVID-19
Background: Although 64 million people has suffered from COPD, studies have shown that 70% of COPD patients worldwide was underdiagnosed due to many reasons. Adequate and fast detection are crucial in determining prognosis of this disease. However, many lungs function test still have disadvantages and limitations. Covid-19 pandemic era has limited our mobility and increase the risk of household air-pollution exposure which increase the risk of COPD. Thus, alternative solutions are needed to detect and screened household air pollution related COPD patients as fast as possible. Discussion: E-nose technology has been proven to effectively detects various respiratory diseases. This could be the alternative solution to provide COPD diagnostic tests which usually use spirometry with its disadvantages. Breath-print based VOC detection could be sensor biomarker for respiratory diseases, even COPD. If this is integrated with primary care systems in Indonesia during Covid-19 pandemic era, it could be the solution in early detection of COPD. Conclusion: Integration of e-nose based breath-print test is potential to be the solution of early and accurate detection of COPD which are non-invasive and patient-well with its advantages.
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