Mac-2结合蛋白糖基化异构体(M2BPGi)与肝脏瞬时弹性成像结果评估慢性乙型肝炎患者肝纤维化的相关性

Haryono Haryono, M. B. Bestari, N. Agustanti, Dolvy Girawan, Yudi Wahyudi, S. Abdurachman, Anna Tjandrawati
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引用次数: 0

摘要

背景:乙型肝炎病毒(HBV)在世界范围内是一个严重的健康问题,包括在印度尼西亚。瞬时弹性成像(TE)现在被认为是慢性乙型肝炎(CHB)患者肝纤维化严重程度分级的可靠替代标志物。糖基化异构体Mac-2结合蛋白(M2BPGi)是一种新的无创血清生物标志物,可用于包括慢性乙型肝炎在内的各种肝脏疾病的肝纤维化分期。本研究旨在评估M2BPGi与肝脏硬度(LS)(通过TE测量)在预测CHB患者肝纤维化中的相关性。方法:于2021年9月至2022年1月在万隆市Hasan Sadikinl总医院对经临床和生化检查诊断为慢性乙型肝炎的患者进行横断面研究。受试者使用Fibroscan®进行TE检查,M2BPGi水平由日本Sysmex公司的自动免疫分析仪HISCL-800检测。统计学分析采用Spearman秩相关法,p值为0.05。结果:共纳入119例CHB患者(M:F = 66:53,中位年龄43岁)。M2BPGi中位值为1.04 COI (0.74-1.59), LS中位值为7.3(5.6-12.5)。M2BPGi与LS呈中度显著相关(r = 0.525;p 0.001)。各纤维化期M2BPGi值中位数F0-F1为0.89 COI, F2为0.88,F3为1.61,F4为2.24 (p < 0.001)。结论:本研究显示CHB患者血清M2BPGi水平与LS呈正相关。
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Correlation of Mac-2 Binding Protein Glycosylation Isomer (M2BPGi) with Liver Transient Elastography Results in Evaluating Liver Fibrosis in Chronic Hepatitis B Patients
Background: Hepatitis B virus (HBV) is a serious health problem in the world, including in Indonesia. Transient elastography (TE) is now regarded as a reliable surrogate marker for grading the severity of liver fibrosis in chronic hepatitis B (CHB) patients. The Mac-2 binding protein of glycosylation isomer (M2BPGi) is a novel non-invasive serum biomarker for liver fibrosis staging in various liver diseases including CHB. This study aims to evaluate the correlation of M2BPGi and liver stiffness (LS), measured through TE, in predicting liver fibrosis among CHB patients.Method: A cross-sectional study was conducted at Dr. Hasan Sadikinl General Hospital Bandung between September 2021–January 2022 on patients diagnosed with CHB based on clinical and biochemical examination. The subjects underwent TE examination using Fibroscan® and M2BPGi levels were determined with an automated immunoassay analyzer HISCL-800, Sysmex, Japan. Statistical analysis was conducted using the Spearman rank correlation method with a significance value of p 0.05.Results: A total of 119 CHB (M:F = 66:53, median age 43 years) patients were consecutively recruited. The median M2BPGi level was 1.04 COI (0.74–1.59) and the median of LS was 7.3 (5.6–12.5). M2BPGi had a moderate and significant correlation with LS (r = 0.525; p 0.001). Median M2BPGi values in each fibrosis stage were 0.89 COI in F0-F1, 0.88 in F2, 1.61 in F3, and 2.24 in F4 (p 0.001).Conclusion: This study revealed a moderate positive correlation between serum M2BPGi level and LS in CHB patients.
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