水生有害物质生态毒理学评价的实地研究

C. Kussatz
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引用次数: 1

摘要

现场试验对化学品管理的作用绝不能被高估。从实地多物种试验中获得的结果无疑提供了关于某种物质命运的宝贵信息,有助于评估实验室试验的结果,只要试验设计以问题的适当表述为导向。如果这些调查是可用的,它们将包括在物质评估中。这些可能会增加不确定性因素,但这只能是一个关键的个案决定。然而,调查必须满足某些最低要求:-检查几种测试浓度和未经处理的对照,证明剂量效应关系,能够得出NOEC;-几个分类类群在较长时期内的暴露;-实验过程中测试浓度的分析控制;-等效开发对照,能够在不同启动条件下重复实验;并采用水生生态参数作为毒理学终点。独立于这些要求之外,验证的必要性在原则上确实存在。©1994 by John Wiley & Sons, Inc.。
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Aquatic field studies in ecotoxicological assessment of hazardous substances
The role of field tests for chemical management must not be overestimated. Results obtained from multi species tests in the field indisputably give valuable information on the fate of a substance that facilitates the assessment of results from laboratory tests provided the test design is orientated on the appropriate formulation of question. If those investigations are available, they are included in the assessment of substances. These may increase the uncertainty factor, but this can only be a critical case-by-case decision. The investigations, however, have to satisfy certain minimum requirements: —examination of several test concentrations and untreated controls, proof of a dose–effect relationship, ability to derive the NOEC; —exposure of several taxonomic groups over a longer period; —analytical control of the test concentration during the experiment; —equivalent development of controls, ability to repeat the experiments under different starting conditions; and —use of aquatic ecological parameters as toxicological end points. Independently of these requirements, the necessity of validation does in principle exist. © 1994 by John Wiley & Sons, Inc..
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