埃塞俄比亚北部艾德尔转诊医院潜在药物相互作用的患病率及临床意义

Teshager Aklilu Yesuf, A. Belay, Eskinder Ayalew Sisay, Zigbey Brhane Gebreamlak
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引用次数: 3

摘要

临床显著的药物-药物相互作用会降低药物的有效性或引起致命的不良事件。虽然有害的药物相互作用是可以预防的,但临床医生对药物相互作用的识别和检测并不理想。目的:评估埃塞俄比亚艾德尔转诊医院内科病房的患病率、临床意义和潜在药物-药物相互作用相关因素。方法:采用横断面研究确定潜在的药物-药物相互作用。采用Micromedex药物相互作用软件对204例患者病历进行药物相互作用分析。数据分析使用SPSS version 16。结果:我们在266个潜在的药物-药物相互作用(pddi)中确定了135个相互作用组合,平均每个患者1.3个pddi。其中,30.1%和53.7%的患者分别至少有一次重度和中度pddi。最常见的pddi是克拉霉素与辛伐他汀同时使用,阿司匹林与肝素同时使用,地塞米松与利福平同时使用,它们分别有禁忌症、重度和中度。pddi的发生与多药相关(p<0.01)。结论:在我院内科病房,潜在的药物相互作用较为普遍。
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Prevalence and Clinical Significance of Potential Drug-Drug Interactions at Ayder Referral Hospital, Northern Ethiopia
Introduction: Clinically significant drug-drug interactions reduce effectiveness of drugs or cause fatal adverse events. Although harmful drug interactions are preventable, clinicians’ recognition and detection of drug interactions is not optimal. Objective: To assess prevalence, clinical significance and factors associated with potential drug-drug interactions at medical ward of Ayder Referral Hospital, Ethiopia. Methods: A cross-sectional study was conducted to determine potential drug-drug interactions. A total of 204 patients’ medical records were analyzed for drug-drug interaction using Micromedex drug interaction software. Data were analyzed using SPSS version 16. Results: We identified 135 interacting-combinations in a total of 266 potential drug-drug interactions (pDDIs) with a mean of 1.3 pDDIs per patient. Of these, 30.1% and 53.7% of patients had at least one major and one moderate pDDIs respectively. The most common pDDIs involved were concurrent use of clarithromycin with simvastatin, aspirin with heparin and dexamethasone with rifampin which have contraindication, major and moderate severity respectively. There was significant association of occurrence of pDDIs with polypharmacy (p<0.01). Conclusion: Potential drug-drug interactions were common at the medical ward of our hospital.
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