生物内部打印参数和混合条件优化的计算流体动力学

IF 6.8 3区 医学 Q1 ENGINEERING, BIOMEDICAL International Journal of Bioprinting Pub Date : 2023-06-22 DOI:10.36922/ijb.0219
Gokhan Ates, P. Bártolo
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引用次数: 0

摘要

组织工程需要制造三维(3D)多材料结构在复杂的几何模仿生物组织的层次结构。为了增加组织工程结构的机械和生物完整性,通过由单个喷嘴组成的打印头连续打印多种材料是至关重要的。在这项工作中,进行了数值分析,以研究两种不同的剪切稀释生物材料溶液(海藻酸盐和明胶)在新型单喷嘴点胶系统中的挤出过程,该系统由药筒和静态混合器组成,用于不同的输入压力,针头几何形状和出口直径。对点胶过程进行了系统的分析,描述了整个打印头的流量、速度场、压降和剪应力分布。定量分析了生物聚合物溶液沿混合室的空间分布,并通过压降值与经验相关性的比较验证了模拟结果。仿真结果表明,所提出的点胶系统能够使物料均匀分布在喷嘴出口。沿所提出的打印头模型的预测剪切应力低于可忽略的细胞损伤的临界剪切值,这表明所提出的点胶系统可用于打印承载细胞的组织工程结构。
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Computational fluid dynamics for the optimization of internal bioprinting parameters and mixing conditions
Tissue engineering requires the fabrication of three-dimensional (3D) multimaterial structures in complex geometries mimicking the hierarchical structure of biological tissues. To increase the mechanical and biological integrity of the tissue engineered structures, continuous printing of multiple materials through a printing head consisting of a single nozzle is crucial. In this work, numerical analysis was carried out to investigate the extrusion process of two different shear-thinning biomaterial solutions (alginate and gelatin) inside a novel single-nozzle dispensing system consisting of cartridges and a static mixer for varying input pressures, needle geometries, and outlet diameters. Systematic analysis of the dispensing process was conducted to describe the flow rate, velocity field, pressure drop, and shear stress distribution throughout the printing head. The spatial distribution of the biopolymer solutions along the mixing chamber was quantitatively analyzed and the simulation results were validated by comparing the pressure drop values with empirical correlations. The simulation results showed that the proposed dispensing system enables to fabricate homogenous material distribution across the nozzle outlet. The predicted shear stress along the proposed printing head model is lower than the critical shear values which correspond to negligible cell damage, suggesting that the proposed dispensing system can be used to print cell-laden tissue engineering constructs.  
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来源期刊
CiteScore
6.90
自引率
4.80%
发文量
81
期刊介绍: The International Journal of Bioprinting is a globally recognized publication that focuses on the advancements, scientific discoveries, and practical implementations of Bioprinting. Bioprinting, in simple terms, involves the utilization of 3D printing technology and materials that contain living cells or biological components to fabricate tissues or other biotechnological products. Our journal encompasses interdisciplinary research that spans across technology, science, and clinical applications within the expansive realm of Bioprinting.
期刊最新文献
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