绿色化学方法下2-氨基噻唑衍生物抗氧化剂的硅研究、分子对接及合成

Dhanshri R. Mali, Anjali Popat Ghuhe, Nikita Murlidhar Khairnar, Sakshi Milind Kothawade
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引用次数: 0

摘要

采用绿色化学方法,利用微波辅助合成了一系列新的2-氨基噻唑衍生物,并用光谱技术和元素分析对其进行了表征。通过分子对接两种不同的氧化还原酶蛋白(PDB: 2CDU和3NM8),测定了衍生物的抗氧化能力。化合物3a和3d与靶蛋白的结合亲和力较强。以抗坏血酸为对照药物对合成药物进行抗氧化活性药理学评价,其中化合物3a的抑制作用最强。
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In silico Study, Molecular Docking and Synthesis of 2-Amino thiazole Derivatives using Green Chemistry Approach as Antioxidant Agent
A series of novel 2-aminothiazole derivatives were synthesized by microwave assisted method as a green chemistry approach and characterized by spectral techniques and elemental analysis. The antioxidant potential of the derivatives was determined by using molecular docking against two different oxidoreductase protein (PDB: 2CDU and 3NM8). Compounds 3a and 3d show the stronger binding affinity to the target protein. The synthesized drug was pharmacologically evaluated for the antioxidant activity using ascorbic acid as a reference drug, where compound 3a showed the highest inhibition.
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