下腹部手术鞘内曲马多与芬太尼佐剂的比较研究

H. Rani, J. Rao, G. Vaishnavi
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引用次数: 0

摘要

长期以来,脊髓麻醉是下腹部手术的首选麻醉方式。然而,这样做的问题是作用时间有限,所以对于长时间的手术需要替代方案。目的:比较小剂量鞘内曲马多和鞘内芬太尼与高压盐酸布比卡因的术中疗效。材料与方法:前瞻性随机对照研究,研究时间为一年。选择50例在脊髓麻醉下择期行下腹部手术的患者,年龄18 ~ 60岁,ASA身体状态I、II级。这些患者被分为两组:BT组-这组患者接受2.5 mL体积的0.5%高压布比卡因和25 mg曲马多鞘内注射。BF组:本组患者给予2.5 mL体积0.5%高压布比卡因加25 μg芬太尼鞘内注射。结果:两组人口统计学参数差异无统计学意义。两个研究组的手术时间差异之间的关联没有统计学意义。两组患者感觉阻滞和运动阻滞的平均发生时间差异的相关性具有可比性,p>0.05;感觉阻滞(镇痛)持续时间和运动阻滞持续时间的差异具有统计学意义,p<0.0000001。3小时与20小时VAS平均评分差异有统计学意义,p<0.05。在BT组中,52%的患者需要2剂镇痛药,48%的患者需要3剂镇痛药。BF组中仅需要1剂镇痛药的占6%,需要2剂镇痛药的占44%。两者差异有统计学意义,p<0.000002。两组手术结束时血流动力学指标的相关性有统计学意义,p<0.05。结论:鞘内芬太尼和曲马多产生相似的感觉和运动阻滞。与曲马多相比,芬太尼提供了更好的术后镇痛时间和质量
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Comparative study of intrathecal tramadol and fentanyl as adjuvants in lower abdominal surgeries
Spinal anesthesia is preferred choice of anesthesia in lower abdominal surgeries for a long time. However, the problem with this is limited duration of action, so for long duration surgeries alternatives are required. The aim: to compare the intra-operative effects of a low dose of intrathecal tramadol and intrathecal fentanyl with hyperbaric bupivacaine hydrochloride. Materials and methods: prospective randomized control study for a duration of study is one year. 50 patients, aged 18 years to 60 years, belonging to ASA physical status I and II, posted for elective lower abdominal surgeries under spinal anaesthesia were chosen. These patients were divided into two groups: group BT- this group of patients received 2.5 mL volume of 0.5 % hyperbaric bupivacaine with 25 mg of tramadol intrathecally. Group BF- this group of patients received 2.5 mL volume of 0.5 % hyperbaric bupivacaine with 25 μg of fentanyl intrathecally. Results: demographic parameters in both the groups are not statistically significant. The association between the differences in duration of surgeries of both the study groups is not statistically. The association between the differences in mean time of onset of sensory block and motor block of both the study groups was comparable with p>0.05 The duration of sensory block (analgesia) and duration of motor block difference between the two means was statistically significant with p<0.0000001. The difference between the mean VAS score at 3 hours and at 20 hours was statistically significant with p<0.05. Among the study BT group, 52 % needed 2 analgesics and 48 % needed 3 doses of analgesics. Among BF group, 6 % needed only one dose of analgesics and 44 % needed 2 doses of analgesics. The difference between the two was statistically significant with p<0.000002. The association between the hemodynamic variables between both the groups at the end of procedure was statistically significant with p<0.05. Conclusions: Intrathecal fentanyl and tramadol produced a similar onset of sensory and motor blocks. Fentanyl provided better duration and quality of postoperative analgesia compared to tramadol
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