先天性心脏缺陷青年人群的局限性、抑郁症状和生活质量

S. Farr, M. Oster, Regina M. Simeone, S. Gilboa, M. Honein
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引用次数: 7

摘要

背景:关于成人先天性心脏缺陷(CHD)的局限性和健康相关生活质量(HRQoL)的基于人群的数据很少。方法:我们使用2004年至2012年医疗支出小组调查数据来确定以人群为基础的样本,这些样本的年龄在18至40岁之间,报告了上一年的健康症状或医疗保健遭遇。将报告冠心病的成年人与其他人进行比较,我们检查了认知、身体和活动限制、抑郁症状以及身心HRQoL的患病率。我们使用卡方检验来检验人口学特征的差异,使用逻辑回归来产生调整患病率(aPR),使用线性回归来检验HRQoL。多变量关联调整了性别、年龄、种族/民族和吸烟状况。所有分析都是在苏丹进行的,使用权重来解释抽样单位内的聚类和无响应。结果59名成人报告冠心病(加权患病率= 0.1%;从2004年到2012年,代表了70万美国成年人(平均每年8万人),54011人没有。除健康保险外,不同冠心病状态的人口统计学特征无显著差异;31.5%的冠心病成年人报告有公共保险,而11.0%的冠心病成年人没有公共保险(p = 0.01)。与他们的同行相比,报告冠心病的成年人在认知(aPR = 2.7, 95%可信区间(CI): 1.0, 7.2)、身体(aPR = 4.0, 95% CI: 1.9, 8.2)和活动限制(aPR = 4.8, 95% CI: 2.6, 9.1)方面的患病率更高,身体HRQoL较差(p = 0.004)。冠心病状态对抑郁症状和精神HRQoL无显著影响。结论与非冠心病患者相比,冠心病患者的身体健康和认知能力受到损害。出生缺陷研究(分册),2016。©2016 Wiley期刊公司
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Limitations, depressive symptoms, and quality of life among a population-based sample of young adults with congenital heart defects.
BACKGROUND Little population-based data exist on limitations and health-related quality of life (HRQoL) in adults with congenital heart defects (CHD). METHODS We used 2004 to 2012 Medical Expenditure Panel Survey data to identify a population-based sample of young adults ages 18 to 40 years reporting health symptoms or healthcare encounters in the previous year. Comparing adults reporting CHD to others, we examined the prevalence of cognitive, physical, and activity limitations, depressive symptoms, and physical and mental HRQoL. We used chi square tests to examine differences in demographic characteristics, logistic regression to generate adjusted prevalence ratios (aPR), and linear regression to examine HRQoL. Multivariable associations were adjusted for sex, age, race/ethnicity, and smoking status. All analyses were conducted in SUDAAN using weights to account for clustering within sampling units and nonresponse. RESULTS Fifty-nine adults reported CHD (weighted prevalence = 0.1%; representing 700,000 U.S. adults from 2004 to 2012 or, on average, 80,000 per year) and 54,011 did not. No demographic characteristics differed significantly by CHD status except health insurance; 31.5% of adults with CHD, compared with 11.0% without, reported public insurance (p = 0.01). Compared with their counterparts, adults reporting CHD had a higher prevalence of cognitive (aPR = 2.7, 95% confidence interval (CI): 1.0, 7.2), physical (aPR = 4.0, 95% CI: 1.9, 8.2), and activity limitations (aPR = 4.8, 95% CI: 2.6, 9.1), and poorer physical HRQoL (p = 0.004). No differences were observed in depressive symptoms and mental HRQoL by CHD status. CONCLUSION Physical health and cognitive abilities of adults with CHD were compromised compared with adults without CHD. Birth Defects Research (Part A) 106:580-586, 2016. © 2016 Wiley Periodicals, Inc.
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来源期刊
Birth defects research. Part A, Clinical and molecular teratology
Birth defects research. Part A, Clinical and molecular teratology 医药科学, 胎儿发育与产前诊断, 生殖系统/围生医学/新生儿
CiteScore
1.86
自引率
0.00%
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0
审稿时长
3 months
期刊最新文献
Issue Information Cover Image Corrigendum for: Levels of folate receptor autoantibodies in maternal and cord blood and risk of neural tube defects in a Chinese population, 106:685–695 (10.1002/bdra.23517) Acardiac twin pregnancies part III: Model simulations. Diprosopus: Systematic review and report of two cases.
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