毒理学剂量x时间=物理常数范式的基础

The Open Pharmacology Journal Pub Date : 2008-08-22 DOI:10.2174/1874143600802010087

K. Rozman

{"title":"毒理学剂量x时间=物理常数范式的基础","authors":"K. Rozman","doi":"10.2174/1874143600802010087","DOIUrl":null,"url":null,"abstract":"The relationship dose x time = constant (mg · hr) has been reported in many toxicological experiments during the past 100 years. It was handled as a curiosity until Rozman and Doull pointed out that it can be found in every experi- ment that is conducted under equilibrium conditions which is called steady state in pharmacology and toxicology. This manuscript suggests that this relationship is consistent with the most basic laws of physics.","PeriodicalId":22907,"journal":{"name":"The Open Pharmacology Journal","volume":"19 1","pages":"87-88"},"PeriodicalIF":0.0000,"publicationDate":"2008-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":"{\"title\":\"The Foundation of Toxicology’s Dose x Time = Constant Paradigm in Physics\",\"authors\":\"K. Rozman\",\"doi\":\"10.2174/1874143600802010087\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"The relationship dose x time = constant (mg · hr) has been reported in many toxicological experiments during the past 100 years. It was handled as a curiosity until Rozman and Doull pointed out that it can be found in every experi- ment that is conducted under equilibrium conditions which is called steady state in pharmacology and toxicology. This manuscript suggests that this relationship is consistent with the most basic laws of physics.\",\"PeriodicalId\":22907,\"journal\":{\"name\":\"The Open Pharmacology Journal\",\"volume\":\"19 1\",\"pages\":\"87-88\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2008-08-22\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"The Open Pharmacology Journal\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.2174/1874143600802010087\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"The Open Pharmacology Journal","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.2174/1874143600802010087","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}

引用次数: 1

摘要

剂量x时间=常数(mg·hr)的关系在近百年来的许多毒理学实验中都有报道。直到Rozman和Doull指出在平衡条件下进行的每一个实验中都可以找到它，在药理学和毒理学中被称为稳态。这份手稿表明，这种关系与最基本的物理定律是一致的。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

The Foundation of Toxicology’s Dose x Time = Constant Paradigm in Physics

The relationship dose x time = constant (mg · hr) has been reported in many toxicological experiments during the past 100 years. It was handled as a curiosity until Rozman and Doull pointed out that it can be found in every experi- ment that is conducted under equilibrium conditions which is called steady state in pharmacology and toxicology. This manuscript suggests that this relationship is consistent with the most basic laws of physics.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

The Open Pharmacology Journal

自引率

0.00%

发文量