应用Who核心药物指标评价抗生素治疗呼吸道感染的处方模式

Yesu Ratnam Melam, Sai Pradeep K, S. P, Naresh R
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摘要

呼吸道感染(RTI)被定义为上呼吸道和下呼吸道的感染性疾病,急性呼吸道感染占综合医院住院患者的12-39%。在Guntur lalitha医院医学部进行了为期6个月的前瞻性观察研究。本研究的目的是分析内科在呼吸道感染中抗生素的使用情况。研究结果显示,100例患者中,下呼吸道感染发生率最高的为90例(90%),下呼吸道感染发生率最高的为10例(10%),其中慢性阻塞性肺病、肺炎、哮喘发生率最高,咽炎、扁桃体炎发生率最高。结果显示,100例患者共使用了107种抗生素,其中青霉素+倍他坦使用率最高(38.31%)。在我们的研究中,开处方者依赖于更高的抗生素,这种做法可能导致抗生素耐药性和其他抗生素耐药性并发症。处方分析显示了实现药物比例使用的途径。不合理用药还可能导致治疗无效和不安全,加重和延长患者的病情、痛苦和伤害。因此,处方审核是必要的,临床药师干预项目应侧重于通过合理的抗生素处方促进感染控制,以尽量减少细菌耐药性的未来出现。为了克服抗生素的不合理使用,该研究建议有必要制定研究地点呼吸道感染的抗生素处方指南。
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Evaluation on Prescribing Pattern of Antibiotics in Treating Respiratory Tract Infections with Who Core Drug Indicators
A respiratory tract infection (RTI) in defined as any infectious disease of the upper and lower respiratory tract Acute respiratory tract infection accounts for 12-39% of the in patients attendance in general hospital. A six months hospital based prospective observational study was carried out in the department of medicine at lalitha hospital, Guntur. The aim of the study was to analyse the prescribing patterns of antibiotic in respiratory tract infection at medicine department. The study results showed that out of 100 patients, more prevalent LRTI were 90 (90%) URTI were 10 (10%) The COPD, pneumonia, asthma were more prominent among LRTIs, whereas Pharyngitis and tonsilitis are prominent among URTI Results showed that for 100 patients 107 antibiotics were prescribed, most widely used antibiotics were penicillin+betalactam (38.31%). In our study the prescribers are relying upon higher antibiotics, this practise may lead to the antibiotic resistance and other complications of antibiotic resistance. Prescription analysis shows the way towards ratio use of drugs. Irrational drug use could also lead to ineffective and unsafe treatment and exacerbation and prolongation of illness, distress and harm to the patients. Hence prescription audit is necessary and the Clinical Pharmacist interventional programs should focus on promoting infections control with rational antibiotic prescription aimed at minimizing the future emergence of bacterial resistance. To overcome the irrational use of antibiotic, the study suggests the need of antibiotic prescribing guidelines for respiratory tract infections at the study site.
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